Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.
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oai:doaj.org-article:29ca3423d6cf4628986d3e91e5d94ada2021-12-02T13:24:16ZIdentification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk10.1038/s41467-018-05074-y2041-1723https://doaj.org/article/29ca3423d6cf4628986d3e91e5d94ada2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05074-yhttps://doaj.org/toc/2041-1723The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.Xuemei JiYohan BosséMaria Teresa LandiJiang GuiXiangjun XiaoDavid QianPhilippe JoubertMaxime LamontagneYafang LiIvan GorlovMariella de BiasiYounghun HanOlga GorlovaRayjean J. HungXifeng WuJames McKayXuchen ZongRobert Carreras-TorresDavid C. ChristianiNeil CaporasoMattias JohanssonGeoffrey LiuStig E. BojesenLoic Le MarchandDemetrios AlbanesHeike BickeböllerMelinda C. AldrichWilliam S. BushAdonina TardonGad RennertChu ChenM. Dawn TeareJohn K. FieldLambertus A. KiemeneyPhilip LazarusAage HaugenStephen LamMatthew B. SchabathAngeline S. AndrewHongbing ShenYun-Chul HongJian-Min YuanPier A. BertazziAngela C. PesatoriYuanqing YeNancy DiaoLi SuRuyang ZhangYonathan BrhaneNatasha LeighlJakob S. JohansenAnders MellemgaardWalid SalibaChristopher HaimanLynne WilkensAna Fernandez-SomoanoGuillermo Fernandez-TardonErik H. F. M. van der HeijdenJin Hee KimJuncheng DaiZhibin HuMichael P. A. DaviesMichael W. MarcusHans BrunnströmJonas ManjerOlle MelanderDavid C. MullerKim OvervadAntonia TrichopoulouRosario TuminoJennifer DohertyGary E. GoodmanAngela CoxFiona TaylorPenella WollIrene BrüskeJudith ManzThomas MuleyAngela RischAlbert RosenbergerKjell GrankvistMikael JohanssonFrances ShepherdMing-Sound TsaoSusanne M. ArnoldEric B. HauraCiprian BolcaIvana HolcatovaVladimir JanoutMilica KonticJolanta LissowskaAnush MukeriaSimona OgnjanovicTadeusz M. OrlowskiGhislaine SceloBeata SwiatkowskaDavid ZaridzePer BakkeVidar SkaugShanbeh ZienolddinyEric J. DuellLesley M. ButlerWoon-Puay KohYu-Tang GaoRichard HoulstonJohn McLaughlinVictoria StevensDavid C. NickleMa’en ObeidatWim TimensBin ZhuLei SongMaría Soler ArtigasMartin D. TobinLouise V. WainFangyi GuJinyoung ByunAhsan KamalDakai ZhuRachel F. TyndaleWei-Qi WeiStephen ChanockPaul BrennanChristopher I. AmosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J. Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C. Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E. Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C. Aldrich William S. Bush Adonina Tardon Gad Rennert Chu Chen M. Dawn Teare John K. Field Lambertus A. Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B. Schabath Angeline S. Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A. Bertazzi Angela C. Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S. Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H. F. M. van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P. A. Davies Michael W. Marcus Hans Brunnström Jonas Manjer Olle Melander David C. Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E. Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M. Arnold Eric B. Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M. Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J. Duell Lesley M. Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C. Nickle Ma’en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D. Tobin Louise V. Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F. Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I. Amos Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
description |
The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology. |
format |
article |
author |
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J. Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C. Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E. Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C. Aldrich William S. Bush Adonina Tardon Gad Rennert Chu Chen M. Dawn Teare John K. Field Lambertus A. Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B. Schabath Angeline S. Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A. Bertazzi Angela C. Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S. Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H. F. M. van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P. A. Davies Michael W. Marcus Hans Brunnström Jonas Manjer Olle Melander David C. Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E. Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M. Arnold Eric B. Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M. Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J. Duell Lesley M. Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C. Nickle Ma’en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D. Tobin Louise V. Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F. Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I. Amos |
author_facet |
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J. Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C. Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E. Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C. Aldrich William S. Bush Adonina Tardon Gad Rennert Chu Chen M. Dawn Teare John K. Field Lambertus A. Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B. Schabath Angeline S. Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A. Bertazzi Angela C. Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S. Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H. F. M. van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P. A. Davies Michael W. Marcus Hans Brunnström Jonas Manjer Olle Melander David C. Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E. Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M. Arnold Eric B. Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M. Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J. Duell Lesley M. Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C. Nickle Ma’en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D. Tobin Louise V. Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F. Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I. Amos |
author_sort |
Xuemei Ji |
title |
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
title_short |
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
title_full |
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
title_fullStr |
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
title_full_unstemmed |
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
title_sort |
identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/29ca3423d6cf4628986d3e91e5d94ada |
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