Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.

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Autores principales: Xuemei Ji, Yohan Bossé, Maria Teresa Landi, Jiang Gui, Xiangjun Xiao, David Qian, Philippe Joubert, Maxime Lamontagne, Yafang Li, Ivan Gorlov, Mariella de Biasi, Younghun Han, Olga Gorlova, Rayjean J. Hung, Xifeng Wu, James McKay, Xuchen Zong, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, M. Dawn Teare, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Aage Haugen, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Hongbing Shen, Yun-Chul Hong, Jian-Min Yuan, Pier A. Bertazzi, Angela C. Pesatori, Yuanqing Ye, Nancy Diao, Li Su, Ruyang Zhang, Yonathan Brhane, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Juncheng Dai, Zhibin Hu, Michael P. A. Davies, Michael W. Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Jennifer Doherty, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Irene Brüske, Judith Manz, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Shanbeh Zienolddiny, Eric J. Duell, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, Ma’en Obeidat, Wim Timens, Bin Zhu, Lei Song, María Soler Artigas, Martin D. Tobin, Louise V. Wain, Fangyi Gu, Jinyoung Byun, Ahsan Kamal, Dakai Zhu, Rachel F. Tyndale, Wei-Qi Wei, Stephen Chanock, Paul Brennan, Christopher I. Amos
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spelling oai:doaj.org-article:29ca3423d6cf4628986d3e91e5d94ada2021-12-02T13:24:16ZIdentification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk10.1038/s41467-018-05074-y2041-1723https://doaj.org/article/29ca3423d6cf4628986d3e91e5d94ada2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05074-yhttps://doaj.org/toc/2041-1723The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.Xuemei JiYohan BosséMaria Teresa LandiJiang GuiXiangjun XiaoDavid QianPhilippe JoubertMaxime LamontagneYafang LiIvan GorlovMariella de BiasiYounghun HanOlga GorlovaRayjean J. HungXifeng WuJames McKayXuchen ZongRobert Carreras-TorresDavid C. ChristianiNeil CaporasoMattias JohanssonGeoffrey LiuStig E. BojesenLoic Le MarchandDemetrios AlbanesHeike BickeböllerMelinda C. AldrichWilliam S. BushAdonina TardonGad RennertChu ChenM. Dawn TeareJohn K. FieldLambertus A. KiemeneyPhilip LazarusAage HaugenStephen LamMatthew B. SchabathAngeline S. AndrewHongbing ShenYun-Chul HongJian-Min YuanPier A. BertazziAngela C. PesatoriYuanqing YeNancy DiaoLi SuRuyang ZhangYonathan BrhaneNatasha LeighlJakob S. JohansenAnders MellemgaardWalid SalibaChristopher HaimanLynne WilkensAna Fernandez-SomoanoGuillermo Fernandez-TardonErik H. F. M. van der HeijdenJin Hee KimJuncheng DaiZhibin HuMichael P. A. DaviesMichael W. MarcusHans BrunnströmJonas ManjerOlle MelanderDavid C. MullerKim OvervadAntonia TrichopoulouRosario TuminoJennifer DohertyGary E. GoodmanAngela CoxFiona TaylorPenella WollIrene BrüskeJudith ManzThomas MuleyAngela RischAlbert RosenbergerKjell GrankvistMikael JohanssonFrances ShepherdMing-Sound TsaoSusanne M. ArnoldEric B. HauraCiprian BolcaIvana HolcatovaVladimir JanoutMilica KonticJolanta LissowskaAnush MukeriaSimona OgnjanovicTadeusz M. OrlowskiGhislaine SceloBeata SwiatkowskaDavid ZaridzePer BakkeVidar SkaugShanbeh ZienolddinyEric J. DuellLesley M. ButlerWoon-Puay KohYu-Tang GaoRichard HoulstonJohn McLaughlinVictoria StevensDavid C. NickleMa’en ObeidatWim TimensBin ZhuLei SongMaría Soler ArtigasMartin D. TobinLouise V. WainFangyi GuJinyoung ByunAhsan KamalDakai ZhuRachel F. TyndaleWei-Qi WeiStephen ChanockPaul BrennanChristopher I. AmosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuemei Ji
Yohan Bossé
Maria Teresa Landi
Jiang Gui
Xiangjun Xiao
David Qian
Philippe Joubert
Maxime Lamontagne
Yafang Li
Ivan Gorlov
Mariella de Biasi
Younghun Han
Olga Gorlova
Rayjean J. Hung
Xifeng Wu
James McKay
Xuchen Zong
Robert Carreras-Torres
David C. Christiani
Neil Caporaso
Mattias Johansson
Geoffrey Liu
Stig E. Bojesen
Loic Le Marchand
Demetrios Albanes
Heike Bickeböller
Melinda C. Aldrich
William S. Bush
Adonina Tardon
Gad Rennert
Chu Chen
M. Dawn Teare
John K. Field
Lambertus A. Kiemeney
Philip Lazarus
Aage Haugen
Stephen Lam
Matthew B. Schabath
Angeline S. Andrew
Hongbing Shen
Yun-Chul Hong
Jian-Min Yuan
Pier A. Bertazzi
Angela C. Pesatori
Yuanqing Ye
Nancy Diao
Li Su
Ruyang Zhang
Yonathan Brhane
Natasha Leighl
Jakob S. Johansen
Anders Mellemgaard
Walid Saliba
Christopher Haiman
Lynne Wilkens
Ana Fernandez-Somoano
Guillermo Fernandez-Tardon
Erik H. F. M. van der Heijden
Jin Hee Kim
Juncheng Dai
Zhibin Hu
Michael P. A. Davies
Michael W. Marcus
Hans Brunnström
Jonas Manjer
Olle Melander
David C. Muller
Kim Overvad
Antonia Trichopoulou
Rosario Tumino
Jennifer Doherty
Gary E. Goodman
Angela Cox
Fiona Taylor
Penella Woll
Irene Brüske
Judith Manz
Thomas Muley
Angela Risch
Albert Rosenberger
Kjell Grankvist
Mikael Johansson
Frances Shepherd
Ming-Sound Tsao
Susanne M. Arnold
Eric B. Haura
Ciprian Bolca
Ivana Holcatova
Vladimir Janout
Milica Kontic
Jolanta Lissowska
Anush Mukeria
Simona Ognjanovic
Tadeusz M. Orlowski
Ghislaine Scelo
Beata Swiatkowska
David Zaridze
Per Bakke
Vidar Skaug
Shanbeh Zienolddiny
Eric J. Duell
Lesley M. Butler
Woon-Puay Koh
Yu-Tang Gao
Richard Houlston
John McLaughlin
Victoria Stevens
David C. Nickle
Ma’en Obeidat
Wim Timens
Bin Zhu
Lei Song
María Soler Artigas
Martin D. Tobin
Louise V. Wain
Fangyi Gu
Jinyoung Byun
Ahsan Kamal
Dakai Zhu
Rachel F. Tyndale
Wei-Qi Wei
Stephen Chanock
Paul Brennan
Christopher I. Amos
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
description The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive ligand receptor interaction in lung cancer etiology.
format article
author Xuemei Ji
Yohan Bossé
Maria Teresa Landi
Jiang Gui
Xiangjun Xiao
David Qian
Philippe Joubert
Maxime Lamontagne
Yafang Li
Ivan Gorlov
Mariella de Biasi
Younghun Han
Olga Gorlova
Rayjean J. Hung
Xifeng Wu
James McKay
Xuchen Zong
Robert Carreras-Torres
David C. Christiani
Neil Caporaso
Mattias Johansson
Geoffrey Liu
Stig E. Bojesen
Loic Le Marchand
Demetrios Albanes
Heike Bickeböller
Melinda C. Aldrich
William S. Bush
Adonina Tardon
Gad Rennert
Chu Chen
M. Dawn Teare
John K. Field
Lambertus A. Kiemeney
Philip Lazarus
Aage Haugen
Stephen Lam
Matthew B. Schabath
Angeline S. Andrew
Hongbing Shen
Yun-Chul Hong
Jian-Min Yuan
Pier A. Bertazzi
Angela C. Pesatori
Yuanqing Ye
Nancy Diao
Li Su
Ruyang Zhang
Yonathan Brhane
Natasha Leighl
Jakob S. Johansen
Anders Mellemgaard
Walid Saliba
Christopher Haiman
Lynne Wilkens
Ana Fernandez-Somoano
Guillermo Fernandez-Tardon
Erik H. F. M. van der Heijden
Jin Hee Kim
Juncheng Dai
Zhibin Hu
Michael P. A. Davies
Michael W. Marcus
Hans Brunnström
Jonas Manjer
Olle Melander
David C. Muller
Kim Overvad
Antonia Trichopoulou
Rosario Tumino
Jennifer Doherty
Gary E. Goodman
Angela Cox
Fiona Taylor
Penella Woll
Irene Brüske
Judith Manz
Thomas Muley
Angela Risch
Albert Rosenberger
Kjell Grankvist
Mikael Johansson
Frances Shepherd
Ming-Sound Tsao
Susanne M. Arnold
Eric B. Haura
Ciprian Bolca
Ivana Holcatova
Vladimir Janout
Milica Kontic
Jolanta Lissowska
Anush Mukeria
Simona Ognjanovic
Tadeusz M. Orlowski
Ghislaine Scelo
Beata Swiatkowska
David Zaridze
Per Bakke
Vidar Skaug
Shanbeh Zienolddiny
Eric J. Duell
Lesley M. Butler
Woon-Puay Koh
Yu-Tang Gao
Richard Houlston
John McLaughlin
Victoria Stevens
David C. Nickle
Ma’en Obeidat
Wim Timens
Bin Zhu
Lei Song
María Soler Artigas
Martin D. Tobin
Louise V. Wain
Fangyi Gu
Jinyoung Byun
Ahsan Kamal
Dakai Zhu
Rachel F. Tyndale
Wei-Qi Wei
Stephen Chanock
Paul Brennan
Christopher I. Amos
author_facet Xuemei Ji
Yohan Bossé
Maria Teresa Landi
Jiang Gui
Xiangjun Xiao
David Qian
Philippe Joubert
Maxime Lamontagne
Yafang Li
Ivan Gorlov
Mariella de Biasi
Younghun Han
Olga Gorlova
Rayjean J. Hung
Xifeng Wu
James McKay
Xuchen Zong
Robert Carreras-Torres
David C. Christiani
Neil Caporaso
Mattias Johansson
Geoffrey Liu
Stig E. Bojesen
Loic Le Marchand
Demetrios Albanes
Heike Bickeböller
Melinda C. Aldrich
William S. Bush
Adonina Tardon
Gad Rennert
Chu Chen
M. Dawn Teare
John K. Field
Lambertus A. Kiemeney
Philip Lazarus
Aage Haugen
Stephen Lam
Matthew B. Schabath
Angeline S. Andrew
Hongbing Shen
Yun-Chul Hong
Jian-Min Yuan
Pier A. Bertazzi
Angela C. Pesatori
Yuanqing Ye
Nancy Diao
Li Su
Ruyang Zhang
Yonathan Brhane
Natasha Leighl
Jakob S. Johansen
Anders Mellemgaard
Walid Saliba
Christopher Haiman
Lynne Wilkens
Ana Fernandez-Somoano
Guillermo Fernandez-Tardon
Erik H. F. M. van der Heijden
Jin Hee Kim
Juncheng Dai
Zhibin Hu
Michael P. A. Davies
Michael W. Marcus
Hans Brunnström
Jonas Manjer
Olle Melander
David C. Muller
Kim Overvad
Antonia Trichopoulou
Rosario Tumino
Jennifer Doherty
Gary E. Goodman
Angela Cox
Fiona Taylor
Penella Woll
Irene Brüske
Judith Manz
Thomas Muley
Angela Risch
Albert Rosenberger
Kjell Grankvist
Mikael Johansson
Frances Shepherd
Ming-Sound Tsao
Susanne M. Arnold
Eric B. Haura
Ciprian Bolca
Ivana Holcatova
Vladimir Janout
Milica Kontic
Jolanta Lissowska
Anush Mukeria
Simona Ognjanovic
Tadeusz M. Orlowski
Ghislaine Scelo
Beata Swiatkowska
David Zaridze
Per Bakke
Vidar Skaug
Shanbeh Zienolddiny
Eric J. Duell
Lesley M. Butler
Woon-Puay Koh
Yu-Tang Gao
Richard Houlston
John McLaughlin
Victoria Stevens
David C. Nickle
Ma’en Obeidat
Wim Timens
Bin Zhu
Lei Song
María Soler Artigas
Martin D. Tobin
Louise V. Wain
Fangyi Gu
Jinyoung Byun
Ahsan Kamal
Dakai Zhu
Rachel F. Tyndale
Wei-Qi Wei
Stephen Chanock
Paul Brennan
Christopher I. Amos
author_sort Xuemei Ji
title Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_short Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_full Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_fullStr Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_full_unstemmed Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
title_sort identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/29ca3423d6cf4628986d3e91e5d94ada
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AT davidcnickle identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT maenobeidat identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT wimtimens identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT binzhu identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT leisong identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT mariasolerartigas identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT martindtobin identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT louisevwain identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT fangyigu identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT jinyoungbyun identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT ahsankamal identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT dakaizhu identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT rachelftyndale identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT weiqiwei identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT stephenchanock identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT paulbrennan identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
AT christopheriamos identificationofsusceptibilitypathwaysfortheroleofchromosome15q251inmodifyinglungcancerrisk
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