Evaluation of 30 DNA damage response and 6 mismatch repair gene mutations as biomarkers for immunotherapy outcomes across multiple solid tumor types

Evaluation of 30 DNA damage response and 6 mismatch repair gene mutations as biomarkers for immunotherapy outcomes across multiple solid tumor types

Objective: DNA damage response (DDR) genes have low mutation rates, which may restrict their clinical applications in predicting the outcomes of immune checkpoint inhibitor (ICI) treatment. Thus, a systemic analysis of multiple DDR genes is needed to identify potential biomarkers of ICI efficacy. Me...

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Autores principales: Zhe Gong, Yue Yang, Jieyun Zhang, Weijian Guo
Formato: article
Lenguaje:EN
Publicado: China Anti-Cancer Association 2021
Materias:
immune checkpoint inhibitor therapy
prediction of efficacy
tumor mutation burden
mismatch repair deficiency
dna damage response genes
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/29cb4935ee744defb0f69f530c0874a9
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