Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease
Qingqing Yin,1,2 Xiaojuan Ji,3 Renjun Lv,1 Jin-Jing Pei,4 Yifeng Du,5 Chao Shen,1 Xunyao Hou1 1Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2Department of Geriatric Neur...
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Dove Medical Press
2020
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oai:doaj.org-article:29cd5ce80323466a80ff32b254f693af2021-12-02T09:13:50ZTargetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease1178-1998https://doaj.org/article/29cd5ce80323466a80ff32b254f693af2020-02-01T00:00:00Zhttps://www.dovepress.com/targetting-exosomes-as-a-new-biomarker-and-therapeutic-approach-for-al-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Qingqing Yin,1,2 Xiaojuan Ji,3 Renjun Lv,1 Jin-Jing Pei,4 Yifeng Du,5 Chao Shen,1 Xunyao Hou1 1Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of China; 3Department of Geriatrics, Beijing Jishuitan Hospital, Beijing 100035, People’s Republic of China; 4Stress Research Institute, Stockholm University, Stockholm 10691, Sweden; 5Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of ChinaCorrespondence: Chao ShenDepartment of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, People’s Republic of ChinaTel +86-53168776133Email 7938911@163.comXunyao HouDepartment of Geriatrics, Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, People’s Republic of ChinaTel +86-53168777165Email hxy6074@163.comAbstract: Alzheimer’s disease (AD) is a neurodegenerative disease that mainly occurs in old age and involves progressive cognitive impairment. AD has become a major global issue for public health, with approximately 24 million people currently affected by the disease. Estimates indicted that this number will quadruple by 2050. Because of the high incidence of AD, there is an urgent need to develop new strategies to diagnose and treat AD. Many recent studies have indicated the multiple, yet somewhat controversial, roles of exosomes in AD. Although the underlying mechanisms by which exosomes play a role in AD are still unknown, current evidence suggests that exosomes can carry and spread toxic amyloid-beta, and hyperphosphorylated tau, between cells, and then induce apoptosis, thus contributing to the loss of neurons. In addition, exosomes appear to possess the ability to reduce brain amyloid-beta, and tau hyperphosphorylation, and transfer neuroprotective substances between neural cells. The accumulating data brings hope that the application of exosomes may be helpful for early diagnostics and the identification of new therapeutic targets for AD. Here, we summarized the various roles of exosomes, and how they might relate to the pathogenesis of AD. We also highlight the potential application of exosomes as a therapeutic option in AD therapy.Keywords: exosomes, alzheimer’s disease, biomarker, mesenchymal stem cells, therapeutic strategyYin QJi XLv RPei JJDu YShen CHou XDove Medical Pressarticleexosomesalzheimer’s diseasebiomarkermesenchymal stem cellstherapeutic strategy GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 195-205 (2020) |
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| topic |
exosomes alzheimer’s disease biomarker mesenchymal stem cells therapeutic strategy Geriatrics RC952-954.6 |
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exosomes alzheimer’s disease biomarker mesenchymal stem cells therapeutic strategy Geriatrics RC952-954.6 Yin Q Ji X Lv R Pei JJ Du Y Shen C Hou X Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease |
| description |
Qingqing Yin,1,2 Xiaojuan Ji,3 Renjun Lv,1 Jin-Jing Pei,4 Yifeng Du,5 Chao Shen,1 Xunyao Hou1 1Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of China; 3Department of Geriatrics, Beijing Jishuitan Hospital, Beijing 100035, People’s Republic of China; 4Stress Research Institute, Stockholm University, Stockholm 10691, Sweden; 5Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of ChinaCorrespondence: Chao ShenDepartment of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, People’s Republic of ChinaTel +86-53168776133Email 7938911@163.comXunyao HouDepartment of Geriatrics, Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, People’s Republic of ChinaTel +86-53168777165Email hxy6074@163.comAbstract: Alzheimer’s disease (AD) is a neurodegenerative disease that mainly occurs in old age and involves progressive cognitive impairment. AD has become a major global issue for public health, with approximately 24 million people currently affected by the disease. Estimates indicted that this number will quadruple by 2050. Because of the high incidence of AD, there is an urgent need to develop new strategies to diagnose and treat AD. Many recent studies have indicated the multiple, yet somewhat controversial, roles of exosomes in AD. Although the underlying mechanisms by which exosomes play a role in AD are still unknown, current evidence suggests that exosomes can carry and spread toxic amyloid-beta, and hyperphosphorylated tau, between cells, and then induce apoptosis, thus contributing to the loss of neurons. In addition, exosomes appear to possess the ability to reduce brain amyloid-beta, and tau hyperphosphorylation, and transfer neuroprotective substances between neural cells. The accumulating data brings hope that the application of exosomes may be helpful for early diagnostics and the identification of new therapeutic targets for AD. Here, we summarized the various roles of exosomes, and how they might relate to the pathogenesis of AD. We also highlight the potential application of exosomes as a therapeutic option in AD therapy.Keywords: exosomes, alzheimer’s disease, biomarker, mesenchymal stem cells, therapeutic strategy |
| format |
article |
| author |
Yin Q Ji X Lv R Pei JJ Du Y Shen C Hou X |
| author_facet |
Yin Q Ji X Lv R Pei JJ Du Y Shen C Hou X |
| author_sort |
Yin Q |
| title |
Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease |
| title_short |
Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease |
| title_full |
Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease |
| title_fullStr |
Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease |
| title_full_unstemmed |
Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease |
| title_sort |
targetting exosomes as a new biomarker and therapeutic approach for alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/29cd5ce80323466a80ff32b254f693af |
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