The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons

The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons

Abstract Messenger RNA m6A modification is shown to regulate local translation in axons. However, how the m6A codes in axonal mRNAs are read and decoded by the m6A reader proteins is still unknown. Here, it is found that the m6A readers YTHDF1 and YTHDF2 are both expressed in cerebellar granule cell...

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Main Authors: Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng‐Jian Ji
Format: article
Language:EN
Published: Wiley 2021
Subjects:
cerebellar parallel fibers
local translation
m6A
YTHDF1
YTHDF2
Science
Q
Online Access:https://doaj.org/article/29ce9c74894b42f3ab2f35e0c7393669
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https://doaj.org/article/29ce9c74894b42f3ab2f35e0c7393669

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