Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)

Bisphenol A (BPA), an organic synthetic compound found in some plastics and epoxy resins, is classified as an endocrine disrupting chemical. Exposure to BPA is especially dangerous if it occurs during specific “critical periods” of life, when organisms are more sensitive to hormonal changes (i.e.,...

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Autores principales:	Brigitta Bonaldo, Antonino Casile, Martina Bettarelli, Stefano Gotti, GianCarlo Panzica, Marilena Marraudino
Formato:	article
Lenguaje:	EN
Publicado:	PAGEPress Publications 2021
Materias:	endocrine disrupting chemicals BPA Three-Chamber Test vasopressin oxytocin paraventricular nucleus Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/29cf20e33d4b4513905429a8d77fad64
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spelling	oai:doaj.org-article:29cf20e33d4b4513905429a8d77fad642021-11-11T07:39:56ZEffects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)10.4081/ejh.2021.32721121-760X2038-8306https://doaj.org/article/29cf20e33d4b4513905429a8d77fad642021-11-01T00:00:00Zhttps://www.ejh.it/index.php/ejh/article/view/3272https://doaj.org/toc/1121-760Xhttps://doaj.org/toc/2038-8306 Bisphenol A (BPA), an organic synthetic compound found in some plastics and epoxy resins, is classified as an endocrine disrupting chemical. Exposure to BPA is especially dangerous if it occurs during specific “critical periods” of life, when organisms are more sensitive to hormonal changes (i.e., intrauterine, perinatal, juvenile or puberty periods). In this study, we focused on the effects of chronic exposure to BPA in adult female mice starting during pregnancy. Three months old C57BL/6J females were orally exposed to BPA or to vehicle (corn oil). The treatment (4 µg/kg body weight/day) started the day 0 of pregnancy and continued throughout pregnancy, lactation, and lasted for a total of 20 weeks. BPA-treated dams did not show differences in body weight or food intake, but they showed an altered estrous cycle compared to the controls. In order to evidence alterations in social and sociosexual behaviors, we performed the Three-Chamber test for sociability, and analyzed two hypothalamic circuits (well-known targets of endocrine disruption) particularly involved in the control of social behavior: the vasopressin and the oxytocin systems. The test revealed some alterations in the displaying of social behavior: BPA-treated dams have higher locomotor activity compared to the control dams, probably a signal of high level of anxiety. In addition, BPA-treated dams spent more time interacting with no-tester females than with no-tester males. In brain sections, we observed a decrease of vasopressin immunoreactivity (only in the paraventricular and suprachiasmatic nuclei) of BPA-treated females, while we did not find any alteration of the oxytocin system. In parallel, we have also observed, in the same hypothalamic nuclei, a significant reduction of the membrane estrogen receptor GPER1 expression. Brigitta BonaldoAntonino CasileMartina BettarelliStefano GottiGianCarlo PanzicaMarilena MarraudinoPAGEPress Publicationsarticleendocrine disrupting chemicalsBPAThree-Chamber Testvasopressinoxytocinparaventricular nucleusBiology (General)QH301-705.5ENEuropean Journal of Histochemistry , Vol 65, Iss s1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endocrine disrupting chemicals BPA Three-Chamber Test vasopressin oxytocin paraventricular nucleus Biology (General) QH301-705.5
spellingShingle	endocrine disrupting chemicals BPA Three-Chamber Test vasopressin oxytocin paraventricular nucleus Biology (General) QH301-705.5 Brigitta Bonaldo Antonino Casile Martina Bettarelli Stefano Gotti GianCarlo Panzica Marilena Marraudino Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
description	Bisphenol A (BPA), an organic synthetic compound found in some plastics and epoxy resins, is classified as an endocrine disrupting chemical. Exposure to BPA is especially dangerous if it occurs during specific “critical periods” of life, when organisms are more sensitive to hormonal changes (i.e., intrauterine, perinatal, juvenile or puberty periods). In this study, we focused on the effects of chronic exposure to BPA in adult female mice starting during pregnancy. Three months old C57BL/6J females were orally exposed to BPA or to vehicle (corn oil). The treatment (4 µg/kg body weight/day) started the day 0 of pregnancy and continued throughout pregnancy, lactation, and lasted for a total of 20 weeks. BPA-treated dams did not show differences in body weight or food intake, but they showed an altered estrous cycle compared to the controls. In order to evidence alterations in social and sociosexual behaviors, we performed the Three-Chamber test for sociability, and analyzed two hypothalamic circuits (well-known targets of endocrine disruption) particularly involved in the control of social behavior: the vasopressin and the oxytocin systems. The test revealed some alterations in the displaying of social behavior: BPA-treated dams have higher locomotor activity compared to the control dams, probably a signal of high level of anxiety. In addition, BPA-treated dams spent more time interacting with no-tester females than with no-tester males. In brain sections, we observed a decrease of vasopressin immunoreactivity (only in the paraventricular and suprachiasmatic nuclei) of BPA-treated females, while we did not find any alteration of the oxytocin system. In parallel, we have also observed, in the same hypothalamic nuclei, a significant reduction of the membrane estrogen receptor GPER1 expression.
format	article
author	Brigitta Bonaldo Antonino Casile Martina Bettarelli Stefano Gotti GianCarlo Panzica Marilena Marraudino
author_facet	Brigitta Bonaldo Antonino Casile Martina Bettarelli Stefano Gotti GianCarlo Panzica Marilena Marraudino
author_sort	Brigitta Bonaldo
title	Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
title_short	Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
title_full	Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
title_fullStr	Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
title_full_unstemmed	Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)
title_sort	effects of chronic exposure to bisphenol a in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (gper1)
publisher	PAGEPress Publications
publishDate	2021
url	https://doaj.org/article/29cf20e33d4b4513905429a8d77fad64
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Effects of chronic exposure to bisphenol A in adult female mice on social behavior, vasopressin system, and estrogen membrane receptor (GPER1)

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