Effect of education on functional network edge efficiency in Alzheimer’s disease

Abstract We investigated the effect of education on the edge efficiency in resting state functional networks (RSFNs) in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease dementia (ADD). We collected the data of 57 early aMCI, 141 late aMCI, 173 mild ADD, and 39 moderate-to-severe ADD...

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Autores principales:	Yeshin Kim, Sung-Woo Kim, Sang Won Seo, Hyemin Jang, Ko Woon Kim, Soo Hyun Cho, Si Eun Kim, Seung Joo Kim, Jin San Lee, Sung Tae Kim, Duk L. Na, Joon-Kyung Seong, Hee Jin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29d002e0a0444b04ad52e9f77b9e4590
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spelling	oai:doaj.org-article:29d002e0a0444b04ad52e9f77b9e45902021-12-02T15:09:07ZEffect of education on functional network edge efficiency in Alzheimer’s disease10.1038/s41598-021-96361-02045-2322https://doaj.org/article/29d002e0a0444b04ad52e9f77b9e45902021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96361-0https://doaj.org/toc/2045-2322Abstract We investigated the effect of education on the edge efficiency in resting state functional networks (RSFNs) in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease dementia (ADD). We collected the data of 57 early aMCI, 141 late aMCI, 173 mild ADD, and 39 moderate-to-severe ADD patients. We used years of education as a proxy for cognitive reserve. We measured edge efficiency for each edge in RSFNs, and performed simple slope analyses to discover their associations with education level among the four groups. In the late aMCI, a sub-network that had hub nodes in the right middle frontal gyrus and the right posterior cingulate gyrus, showed a positive association between RSFN edge efficiency and education (threshold = 2.5, p = 0.0478). There was no negative effect of education on the RSFN edge efficiency. In the early aMCI, mild ADD, and moderate-to-severe ADD, there were no sub-networks showing positive or negative correlation between education and RSFN edge efficiency. There was a positive effect of higher education on RSFN edge efficiency in the late aMCI, but not in the early aMCI or ADD. This indicates that in late aMCI, those who have higher education level have greater ability to resist collapsed functional network.Yeshin KimSung-Woo KimSang Won SeoHyemin JangKo Woon KimSoo Hyun ChoSi Eun KimSeung Joo KimJin San LeeSung Tae KimDuk L. NaJoon-Kyung SeongHee Jin KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeshin Kim Sung-Woo Kim Sang Won Seo Hyemin Jang Ko Woon Kim Soo Hyun Cho Si Eun Kim Seung Joo Kim Jin San Lee Sung Tae Kim Duk L. Na Joon-Kyung Seong Hee Jin Kim Effect of education on functional network edge efficiency in Alzheimer’s disease
description	Abstract We investigated the effect of education on the edge efficiency in resting state functional networks (RSFNs) in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease dementia (ADD). We collected the data of 57 early aMCI, 141 late aMCI, 173 mild ADD, and 39 moderate-to-severe ADD patients. We used years of education as a proxy for cognitive reserve. We measured edge efficiency for each edge in RSFNs, and performed simple slope analyses to discover their associations with education level among the four groups. In the late aMCI, a sub-network that had hub nodes in the right middle frontal gyrus and the right posterior cingulate gyrus, showed a positive association between RSFN edge efficiency and education (threshold = 2.5, p = 0.0478). There was no negative effect of education on the RSFN edge efficiency. In the early aMCI, mild ADD, and moderate-to-severe ADD, there were no sub-networks showing positive or negative correlation between education and RSFN edge efficiency. There was a positive effect of higher education on RSFN edge efficiency in the late aMCI, but not in the early aMCI or ADD. This indicates that in late aMCI, those who have higher education level have greater ability to resist collapsed functional network.
format	article
author	Yeshin Kim Sung-Woo Kim Sang Won Seo Hyemin Jang Ko Woon Kim Soo Hyun Cho Si Eun Kim Seung Joo Kim Jin San Lee Sung Tae Kim Duk L. Na Joon-Kyung Seong Hee Jin Kim
author_facet	Yeshin Kim Sung-Woo Kim Sang Won Seo Hyemin Jang Ko Woon Kim Soo Hyun Cho Si Eun Kim Seung Joo Kim Jin San Lee Sung Tae Kim Duk L. Na Joon-Kyung Seong Hee Jin Kim
author_sort	Yeshin Kim
title	Effect of education on functional network edge efficiency in Alzheimer’s disease
title_short	Effect of education on functional network edge efficiency in Alzheimer’s disease
title_full	Effect of education on functional network edge efficiency in Alzheimer’s disease
title_fullStr	Effect of education on functional network edge efficiency in Alzheimer’s disease
title_full_unstemmed	Effect of education on functional network edge efficiency in Alzheimer’s disease
title_sort	effect of education on functional network edge efficiency in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29d002e0a0444b04ad52e9f77b9e4590
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Effect of education on functional network edge efficiency in Alzheimer’s disease

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