A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.

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Autores principales: Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L. Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel S. W. Tan, N. Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S. Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline S. J. Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H. Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/29d0a642abdc45549ef07f126485d155
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spelling oai:doaj.org-article:29d0a642abdc45549ef07f126485d1552021-12-02T17:31:40ZA common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma10.1038/s41467-020-15318-52041-1723https://doaj.org/article/29d0a642abdc45549ef07f126485d1552020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15318-5https://doaj.org/toc/2041-1723The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.Li Ren KongNur Afiqah Binte Mohamed SallehRichard Weijie OngTuan Zea TanNicholas L. SynRobby Miguel GohChee Wai FhuDaniel S. W. TanN. Gopalakrishna IyerSrinivasaraghavan KannanChandra S. VermaYaw Chyn LimRoss SooJingshan HoYiqing HuangJoline S. J. LimBenedict Junrong YanMin En NgaSeng Gee LimH. Phillip KoefflerSoo Chin LeeDennis KappeiHuynh The HungBoon Cher GohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Li Ren Kong
Nur Afiqah Binte Mohamed Salleh
Richard Weijie Ong
Tuan Zea Tan
Nicholas L. Syn
Robby Miguel Goh
Chee Wai Fhu
Daniel S. W. Tan
N. Gopalakrishna Iyer
Srinivasaraghavan Kannan
Chandra S. Verma
Yaw Chyn Lim
Ross Soo
Jingshan Ho
Yiqing Huang
Joline S. J. Lim
Benedict Junrong Yan
Min En Nga
Seng Gee Lim
H. Phillip Koeffler
Soo Chin Lee
Dennis Kappei
Huynh The Hung
Boon Cher Goh
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
description The MET receptor is frequently activated in cancer. Here, the authors show that in head and neck and lung squamous carcinoma, a polymorphic MET variant enhances binding to HER2, resulting in activation of HER2 signalling and progression of the cancers.
format article
author Li Ren Kong
Nur Afiqah Binte Mohamed Salleh
Richard Weijie Ong
Tuan Zea Tan
Nicholas L. Syn
Robby Miguel Goh
Chee Wai Fhu
Daniel S. W. Tan
N. Gopalakrishna Iyer
Srinivasaraghavan Kannan
Chandra S. Verma
Yaw Chyn Lim
Ross Soo
Jingshan Ho
Yiqing Huang
Joline S. J. Lim
Benedict Junrong Yan
Min En Nga
Seng Gee Lim
H. Phillip Koeffler
Soo Chin Lee
Dennis Kappei
Huynh The Hung
Boon Cher Goh
author_facet Li Ren Kong
Nur Afiqah Binte Mohamed Salleh
Richard Weijie Ong
Tuan Zea Tan
Nicholas L. Syn
Robby Miguel Goh
Chee Wai Fhu
Daniel S. W. Tan
N. Gopalakrishna Iyer
Srinivasaraghavan Kannan
Chandra S. Verma
Yaw Chyn Lim
Ross Soo
Jingshan Ho
Yiqing Huang
Joline S. J. Lim
Benedict Junrong Yan
Min En Nga
Seng Gee Lim
H. Phillip Koeffler
Soo Chin Lee
Dennis Kappei
Huynh The Hung
Boon Cher Goh
author_sort Li Ren Kong
title A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
title_short A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
title_full A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
title_fullStr A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
title_full_unstemmed A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
title_sort common met polymorphism harnesses her2 signaling to drive aggressive squamous cell carcinoma
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/29d0a642abdc45549ef07f126485d155
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