Albumin platelet product as a novel score for liver fibrosis stage and prognosis

Abstract Fibrosis-4 index, a conventional biomarker for liver fibrosis stage, is confounded by age and hepatitis activity grade. The current retrospective multicenter study aimed to formulate the novel indices of liver fibrosis by mathematically combining items of peripheral blood examination and to...

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Autores principales:	Koji Fujita, Kazumi Yamasaki, Asahiro Morishita, Tingting Shi, Joji Tani, Noriko Nishiyama, Hideki Kobara, Takashi Himoto, Hiroshi Yatsuhashi, Tsutomu Masaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29d0cb831f074a23917c4430a683bf0f
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spelling	oai:doaj.org-article:29d0cb831f074a23917c4430a683bf0f2021-12-02T11:37:18ZAlbumin platelet product as a novel score for liver fibrosis stage and prognosis10.1038/s41598-021-84719-32045-2322https://doaj.org/article/29d0cb831f074a23917c4430a683bf0f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84719-3https://doaj.org/toc/2045-2322Abstract Fibrosis-4 index, a conventional biomarker for liver fibrosis stage, is confounded by age and hepatitis activity grade. The current retrospective multicenter study aimed to formulate the novel indices of liver fibrosis by mathematically combining items of peripheral blood examination and to evaluate ability of prognosis prediction. After a novel index was established in a training cohort, the index was tested in a validation cohort. Briefly, a total of 426 patients were enrolled in a training cohort. Albumin and platelet most strongly correlated to fibrosis stage among blood examination. Albumin platelet product (APP) = Albumin × platelet/1000 could differentiate the four stages of liver fibrosis (p < 0.05). APP indicated fibrosis stage independent from hepatitis activity grade. A cut-off value = 4.349 diagnosed cirrhosis with area under ROC more than 0.8. Multivariate analysis revealed that smaller APP independently contributed to HCC prevalence and overall mortality. The results were validated in another 707 patients with HCV infection. In conclusion, APP was not confounded by age or hepatitis activity grade contrary to Fibrosis-4 index. APP is as simple as physicians can calculate it by pen calculation. The product serves physicians in managing patients with chronic liver disease.Koji FujitaKazumi YamasakiAsahiro MorishitaTingting ShiJoji TaniNoriko NishiyamaHideki KobaraTakashi HimotoHiroshi YatsuhashiTsutomu MasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koji Fujita Kazumi Yamasaki Asahiro Morishita Tingting Shi Joji Tani Noriko Nishiyama Hideki Kobara Takashi Himoto Hiroshi Yatsuhashi Tsutomu Masaki Albumin platelet product as a novel score for liver fibrosis stage and prognosis
description	Abstract Fibrosis-4 index, a conventional biomarker for liver fibrosis stage, is confounded by age and hepatitis activity grade. The current retrospective multicenter study aimed to formulate the novel indices of liver fibrosis by mathematically combining items of peripheral blood examination and to evaluate ability of prognosis prediction. After a novel index was established in a training cohort, the index was tested in a validation cohort. Briefly, a total of 426 patients were enrolled in a training cohort. Albumin and platelet most strongly correlated to fibrosis stage among blood examination. Albumin platelet product (APP) = Albumin × platelet/1000 could differentiate the four stages of liver fibrosis (p < 0.05). APP indicated fibrosis stage independent from hepatitis activity grade. A cut-off value = 4.349 diagnosed cirrhosis with area under ROC more than 0.8. Multivariate analysis revealed that smaller APP independently contributed to HCC prevalence and overall mortality. The results were validated in another 707 patients with HCV infection. In conclusion, APP was not confounded by age or hepatitis activity grade contrary to Fibrosis-4 index. APP is as simple as physicians can calculate it by pen calculation. The product serves physicians in managing patients with chronic liver disease.
format	article
author	Koji Fujita Kazumi Yamasaki Asahiro Morishita Tingting Shi Joji Tani Noriko Nishiyama Hideki Kobara Takashi Himoto Hiroshi Yatsuhashi Tsutomu Masaki
author_facet	Koji Fujita Kazumi Yamasaki Asahiro Morishita Tingting Shi Joji Tani Noriko Nishiyama Hideki Kobara Takashi Himoto Hiroshi Yatsuhashi Tsutomu Masaki
author_sort	Koji Fujita
title	Albumin platelet product as a novel score for liver fibrosis stage and prognosis
title_short	Albumin platelet product as a novel score for liver fibrosis stage and prognosis
title_full	Albumin platelet product as a novel score for liver fibrosis stage and prognosis
title_fullStr	Albumin platelet product as a novel score for liver fibrosis stage and prognosis
title_full_unstemmed	Albumin platelet product as a novel score for liver fibrosis stage and prognosis
title_sort	albumin platelet product as a novel score for liver fibrosis stage and prognosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29d0cb831f074a23917c4430a683bf0f
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Albumin platelet product as a novel score for liver fibrosis stage and prognosis

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