Tau association with synaptic vesicles causes presynaptic dysfunction

Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.

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Autores principales:	Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518
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spelling	oai:doaj.org-article:29d0e0f57e0642e99099f85ef88b25182021-12-02T17:06:18ZTau association with synaptic vesicles causes presynaptic dysfunction10.1038/ncomms152952041-1723https://doaj.org/article/29d0e0f57e0642e99099f85ef88b25182017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15295https://doaj.org/toc/2041-1723Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.Lujia ZhouJoseph McInnesKeimpe WierdaMatthew HoltAbigail G. HerrmannRosemary J. JacksonYu-Chun WangJef SwertsJelle BeyensKatarzyna MiskiewiczSven VilainIlse DewachterDiederik MoecharsBart De StrooperTara L. Spires-JonesJoris De WitPatrik VerstrekenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lujia Zhou Joseph McInnes Keimpe Wierda Matthew Holt Abigail G. Herrmann Rosemary J. Jackson Yu-Chun Wang Jef Swerts Jelle Beyens Katarzyna Miskiewicz Sven Vilain Ilse Dewachter Diederik Moechars Bart De Strooper Tara L. Spires-Jones Joris De Wit Patrik Verstreken Tau association with synaptic vesicles causes presynaptic dysfunction
description	Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
format	article
author	Lujia Zhou Joseph McInnes Keimpe Wierda Matthew Holt Abigail G. Herrmann Rosemary J. Jackson Yu-Chun Wang Jef Swerts Jelle Beyens Katarzyna Miskiewicz Sven Vilain Ilse Dewachter Diederik Moechars Bart De Strooper Tara L. Spires-Jones Joris De Wit Patrik Verstreken
author_facet	Lujia Zhou Joseph McInnes Keimpe Wierda Matthew Holt Abigail G. Herrmann Rosemary J. Jackson Yu-Chun Wang Jef Swerts Jelle Beyens Katarzyna Miskiewicz Sven Vilain Ilse Dewachter Diederik Moechars Bart De Strooper Tara L. Spires-Jones Joris De Wit Patrik Verstreken
author_sort	Lujia Zhou
title	Tau association with synaptic vesicles causes presynaptic dysfunction
title_short	Tau association with synaptic vesicles causes presynaptic dysfunction
title_full	Tau association with synaptic vesicles causes presynaptic dysfunction
title_fullStr	Tau association with synaptic vesicles causes presynaptic dysfunction
title_full_unstemmed	Tau association with synaptic vesicles causes presynaptic dysfunction
title_sort	tau association with synaptic vesicles causes presynaptic dysfunction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518
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Tau association with synaptic vesicles causes presynaptic dysfunction

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