Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles

Abstract Magnetic nanoparticles dissipate heat when exposed to alternating magnetic fields (AMFs), making them suitable for cancer hyperthermia. Therapeutic heating applications demand accurate characterization of the heating power dissipated by the particles. Specific loss power (SLP) generated by...

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Autores principales:	Frederik Soetaert, Sri Kamal Kandala, Andris Bakuzis, Robert Ivkov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29d1a107e539435e8a1bf74557a805aa
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spelling	oai:doaj.org-article:29d1a107e539435e8a1bf74557a805aa2021-12-02T12:32:17ZExperimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles10.1038/s41598-017-07088-w2045-2322https://doaj.org/article/29d1a107e539435e8a1bf74557a805aa2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07088-whttps://doaj.org/toc/2045-2322Abstract Magnetic nanoparticles dissipate heat when exposed to alternating magnetic fields (AMFs), making them suitable for cancer hyperthermia. Therapeutic heating applications demand accurate characterization of the heating power dissipated by the particles. Specific loss power (SLP) generated by magnetic nanoparticles is estimated from calorimetric heating measurements. Such measurements require adiabatic conditions, yet they are typically performed in an AMF device with non-adiabatic conditions. We have measured heating from four magnetic nanoparticle constructs using a range of frequencies (150–375 kHz) and magnetic fields (4–44 kA/m). We have extended a method developed to estimate SLP from the inherently non-adiabatic measurements, where we identify data ranges that conform to (quasi)-adiabatic conditions. Each time interval of measurement that met a predetermined criterion was used to generate a value of SLP, and the mean from all estimates was selected as the estimated SLP. Despite the application of rigorous selection criteria, measured temperature data displayed variability at specific heating loads resulting in larger variance of calculated mean SLP values. Overall, the results show a linear dependence of the SLP with AMF frequency, as anticipated by current models. Conversely, measured amplitude-dependent SLP profiles of all studied constructs conform to no predictions of current models.Frederik SoetaertSri Kamal KandalaAndris BakuzisRobert IvkovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Frederik Soetaert Sri Kamal Kandala Andris Bakuzis Robert Ivkov Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
description	Abstract Magnetic nanoparticles dissipate heat when exposed to alternating magnetic fields (AMFs), making them suitable for cancer hyperthermia. Therapeutic heating applications demand accurate characterization of the heating power dissipated by the particles. Specific loss power (SLP) generated by magnetic nanoparticles is estimated from calorimetric heating measurements. Such measurements require adiabatic conditions, yet they are typically performed in an AMF device with non-adiabatic conditions. We have measured heating from four magnetic nanoparticle constructs using a range of frequencies (150–375 kHz) and magnetic fields (4–44 kA/m). We have extended a method developed to estimate SLP from the inherently non-adiabatic measurements, where we identify data ranges that conform to (quasi)-adiabatic conditions. Each time interval of measurement that met a predetermined criterion was used to generate a value of SLP, and the mean from all estimates was selected as the estimated SLP. Despite the application of rigorous selection criteria, measured temperature data displayed variability at specific heating loads resulting in larger variance of calculated mean SLP values. Overall, the results show a linear dependence of the SLP with AMF frequency, as anticipated by current models. Conversely, measured amplitude-dependent SLP profiles of all studied constructs conform to no predictions of current models.
format	article
author	Frederik Soetaert Sri Kamal Kandala Andris Bakuzis Robert Ivkov
author_facet	Frederik Soetaert Sri Kamal Kandala Andris Bakuzis Robert Ivkov
author_sort	Frederik Soetaert
title	Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
title_short	Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
title_full	Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
title_fullStr	Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
title_full_unstemmed	Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
title_sort	experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29d1a107e539435e8a1bf74557a805aa
work_keys_str_mv	AT frederiksoetaert experimentalestimationandanalysisofvarianceofthemeasuredlosspowerofmagneticnanoparticles AT srikamalkandala experimentalestimationandanalysisofvarianceofthemeasuredlosspowerofmagneticnanoparticles AT andrisbakuzis experimentalestimationandanalysisofvarianceofthemeasuredlosspowerofmagneticnanoparticles AT robertivkov experimentalestimationandanalysisofvarianceofthemeasuredlosspowerofmagneticnanoparticles
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Experimental estimation and analysis of variance of the measured loss power of magnetic nanoparticles

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