Exploring the Ligand Efficacy of Cannabinoid Receptor 1 (CB1) using Molecular Dynamics Simulations

Exploring the Ligand Efficacy of Cannabinoid Receptor 1 (CB1) using Molecular Dynamics Simulations

Abstract Cannabinoid receptor 1 (CB1) is a promising therapeutic target for a variety of disorders. Distinct efficacy profiles showed different therapeutic effects on CB1 dependent on three classes of ligands: agonists, antagonists, and inverse agonists. To discriminate the distinct efficacy profile...

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Detalles Bibliográficos
Autores principales: Sang Won Jung, Art E. Cho, Wookyung Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Cannabinoid Receptor (CB1)
Ligand Efficacy
Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA)
Binding Free Energy
Active Conformation
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/29d497457f834dadb0833af41d4d3654
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https://doaj.org/article/29d497457f834dadb0833af41d4d3654

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