Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients

Mitochondrial calcium signaling plays an important role in neuronal bioenergetics yet its regulation by brain activity in vivo is not understood. Here, the authors show that mitochondrial and cytosolic calcium transients are dynamically coupled as a function of brain activity.

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Bibliographic Details
Main Authors: Yuan Lin, Lin-Lin Li, Wei Nie, Xiaolei Liu, Avital Adler, Chi Xiao, Fujian Lu, Liping Wang, Hua Han, Xianhua Wang, Wen-Biao Gan, Heping Cheng
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/29d6d5edd7164898ae9ffc3ca5668d1c
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Summary:Mitochondrial calcium signaling plays an important role in neuronal bioenergetics yet its regulation by brain activity in vivo is not understood. Here, the authors show that mitochondrial and cytosolic calcium transients are dynamically coupled as a function of brain activity.