Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

It is unclear what causes variation in cell death in response to chemotherapy. Here, the authors show that cellular mitochondrial content modulates apoptotic protein levels, which in turn regulates response to agents such as TRAIL.

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Bibliographic Details
Main Authors:	Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes, Francisco J. Iborra
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/29db1d8ce1734f508ff800f6141230b0
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spelling	oai:doaj.org-article:29db1d8ce1734f508ff800f6141230b02021-12-02T14:39:06ZMitochondrial levels determine variability in cell death by modulating apoptotic gene expression10.1038/s41467-017-02787-42041-1723https://doaj.org/article/29db1d8ce1734f508ff800f6141230b02018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02787-4https://doaj.org/toc/2041-1723It is unclear what causes variation in cell death in response to chemotherapy. Here, the authors show that cellular mitochondrial content modulates apoptotic protein levels, which in turn regulates response to agents such as TRAIL.Silvia Márquez-JuradoJuan Díaz-ColungaRicardo Pires das NevesAntonio Martinez-LorenteFernando AlmazánRaúl GuantesFrancisco J. IborraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Márquez-Jurado Juan Díaz-Colunga Ricardo Pires das Neves Antonio Martinez-Lorente Fernando Almazán Raúl Guantes Francisco J. Iborra Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
description	It is unclear what causes variation in cell death in response to chemotherapy. Here, the authors show that cellular mitochondrial content modulates apoptotic protein levels, which in turn regulates response to agents such as TRAIL.
format	article
author	Silvia Márquez-Jurado Juan Díaz-Colunga Ricardo Pires das Neves Antonio Martinez-Lorente Fernando Almazán Raúl Guantes Francisco J. Iborra
author_facet	Silvia Márquez-Jurado Juan Díaz-Colunga Ricardo Pires das Neves Antonio Martinez-Lorente Fernando Almazán Raúl Guantes Francisco J. Iborra
author_sort	Silvia Márquez-Jurado
title	Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
title_short	Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
title_full	Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
title_fullStr	Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
title_full_unstemmed	Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
title_sort	mitochondrial levels determine variability in cell death by modulating apoptotic gene expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/29db1d8ce1734f508ff800f6141230b0
work_keys_str_mv	AT silviamarquezjurado mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression AT juandiazcolunga mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression AT ricardopiresdasneves mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression AT antoniomartinezlorente mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression AT fernandoalmazan mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression AT raulguantes mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression AT franciscojiborra mitochondriallevelsdeterminevariabilityincelldeathbymodulatingapoptoticgeneexpression
_version_	1718390704544153600

Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression

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