Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

Central axons have limited regenerative ability following injury. Here, the authors show that chronic activation of DRG neurons results in highly dynamic microtubules at the distal axons and enhanced axonal regrowth and synaptogenesis in the spinal cord affecting functional recovery.

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Autores principales:	Di Wu, Ying Jin, Tatiana M. Shapiro, Abhishek Hinduja, Peter W. Baas, Veronica J. Tom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29dfd0fe65224658b1b222872c7de523
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spelling	oai:doaj.org-article:29dfd0fe65224658b1b222872c7de5232021-12-02T16:49:30ZChronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury10.1038/s41467-020-19914-32041-1723https://doaj.org/article/29dfd0fe65224658b1b222872c7de5232020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19914-3https://doaj.org/toc/2041-1723Central axons have limited regenerative ability following injury. Here, the authors show that chronic activation of DRG neurons results in highly dynamic microtubules at the distal axons and enhanced axonal regrowth and synaptogenesis in the spinal cord affecting functional recovery.Di WuYing JinTatiana M. ShapiroAbhishek HindujaPeter W. BaasVeronica J. TomNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Di Wu Ying Jin Tatiana M. Shapiro Abhishek Hinduja Peter W. Baas Veronica J. Tom Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
description	Central axons have limited regenerative ability following injury. Here, the authors show that chronic activation of DRG neurons results in highly dynamic microtubules at the distal axons and enhanced axonal regrowth and synaptogenesis in the spinal cord affecting functional recovery.
format	article
author	Di Wu Ying Jin Tatiana M. Shapiro Abhishek Hinduja Peter W. Baas Veronica J. Tom
author_facet	Di Wu Ying Jin Tatiana M. Shapiro Abhishek Hinduja Peter W. Baas Veronica J. Tom
author_sort	Di Wu
title	Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
title_short	Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
title_full	Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
title_fullStr	Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
title_full_unstemmed	Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
title_sort	chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/29dfd0fe65224658b1b222872c7de523
work_keys_str_mv	AT diwu chronicneuronalactivationincreasesdynamicmicrotubulestoenhancefunctionalaxonregenerationafterdorsalrootcrushinjury AT yingjin chronicneuronalactivationincreasesdynamicmicrotubulestoenhancefunctionalaxonregenerationafterdorsalrootcrushinjury AT tatianamshapiro chronicneuronalactivationincreasesdynamicmicrotubulestoenhancefunctionalaxonregenerationafterdorsalrootcrushinjury AT abhishekhinduja chronicneuronalactivationincreasesdynamicmicrotubulestoenhancefunctionalaxonregenerationafterdorsalrootcrushinjury AT peterwbaas chronicneuronalactivationincreasesdynamicmicrotubulestoenhancefunctionalaxonregenerationafterdorsalrootcrushinjury AT veronicajtom chronicneuronalactivationincreasesdynamicmicrotubulestoenhancefunctionalaxonregenerationafterdorsalrootcrushinjury
_version_	1718383266953691136

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

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