Biodegradable polymer hydrogel‐based tissue adhesives: A review

Abstract Tissue‐adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but are not biodegradable. However, the long‐term presence of non‐bio...

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Autores principales: Xin Zhang, Yanan Jiang, Lu Han, Xiong Lu
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Lenguaje:EN
Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/29e1b04a46d24574bd1d4620f2dd8f30
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spelling oai:doaj.org-article:29e1b04a46d24574bd1d4620f2dd8f302021-11-12T15:58:03ZBiodegradable polymer hydrogel‐based tissue adhesives: A review2405-451810.1049/bsb2.12016https://doaj.org/article/29e1b04a46d24574bd1d4620f2dd8f302021-12-01T00:00:00Zhttps://doi.org/10.1049/bsb2.12016https://doaj.org/toc/2405-4518Abstract Tissue‐adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but are not biodegradable. However, the long‐term presence of non‐biodegradable adhesives in the body can cause secondary harm to the patient. An ideal tissue adhesive should meet the following requirements: good adhesiveness, biodegradability, low cytotoxicity, and minimal inflammatory response. Natural polymers with inherent biodegradation and biocompatibility show great potentials in biomedical engineering, and the development of tissue adhesives based on natural polymers has become a hot topic in biomaterials science. This review systematically summarises the latest progresses in biodegradable tissue adhesives based on natural polymers, such as chitosan, hyaluronic acid, alginate, gelatin, dextran, and cellulose. Methods for preparing natural polymer tissue adhesives are summarised and their advantages and disadvantages are discussed. Finally, potential trends in the future direction of biodegradable tissue adhesives are discussed.Xin ZhangYanan JiangLu HanXiong LuWileyarticlebiodegradable hydrogelstissue adhesivewound healingBiotechnologyTP248.13-248.65BiochemistryQD415-436ENBiosurface and Biotribology, Vol 7, Iss 4, Pp 163-179 (2021)
institution DOAJ
collection DOAJ
language EN
topic biodegradable hydrogels
tissue adhesive
wound healing
Biotechnology
TP248.13-248.65
Biochemistry
QD415-436
spellingShingle biodegradable hydrogels
tissue adhesive
wound healing
Biotechnology
TP248.13-248.65
Biochemistry
QD415-436
Xin Zhang
Yanan Jiang
Lu Han
Xiong Lu
Biodegradable polymer hydrogel‐based tissue adhesives: A review
description Abstract Tissue‐adhesive materials are emerging biomaterials with potential applications in wound healing patches, tissue sealants, and haemostat materials. Tissue adhesives based on synthetic polymers generally have good adhesion but are not biodegradable. However, the long‐term presence of non‐biodegradable adhesives in the body can cause secondary harm to the patient. An ideal tissue adhesive should meet the following requirements: good adhesiveness, biodegradability, low cytotoxicity, and minimal inflammatory response. Natural polymers with inherent biodegradation and biocompatibility show great potentials in biomedical engineering, and the development of tissue adhesives based on natural polymers has become a hot topic in biomaterials science. This review systematically summarises the latest progresses in biodegradable tissue adhesives based on natural polymers, such as chitosan, hyaluronic acid, alginate, gelatin, dextran, and cellulose. Methods for preparing natural polymer tissue adhesives are summarised and their advantages and disadvantages are discussed. Finally, potential trends in the future direction of biodegradable tissue adhesives are discussed.
format article
author Xin Zhang
Yanan Jiang
Lu Han
Xiong Lu
author_facet Xin Zhang
Yanan Jiang
Lu Han
Xiong Lu
author_sort Xin Zhang
title Biodegradable polymer hydrogel‐based tissue adhesives: A review
title_short Biodegradable polymer hydrogel‐based tissue adhesives: A review
title_full Biodegradable polymer hydrogel‐based tissue adhesives: A review
title_fullStr Biodegradable polymer hydrogel‐based tissue adhesives: A review
title_full_unstemmed Biodegradable polymer hydrogel‐based tissue adhesives: A review
title_sort biodegradable polymer hydrogel‐based tissue adhesives: a review
publisher Wiley
publishDate 2021
url https://doaj.org/article/29e1b04a46d24574bd1d4620f2dd8f30
work_keys_str_mv AT xinzhang biodegradablepolymerhydrogelbasedtissueadhesivesareview
AT yananjiang biodegradablepolymerhydrogelbasedtissueadhesivesareview
AT luhan biodegradablepolymerhydrogelbasedtissueadhesivesareview
AT xionglu biodegradablepolymerhydrogelbasedtissueadhesivesareview
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