Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

Background: The outbreak of Coronavirus disease 2019 (COVID-19) has caused more than 180 million infections and 3.9 million deaths. To date, emerging clinical evidence has shown the synergetic benefits of Chinese herbal injections in treating this contagious respiratory disease. This review aims to...

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Autores principales:	Xiao-Bin Zhu, Meng Guo, Zhi-Hui Zhang, Li-Hua Sun, Lei Liu, Li-Juan Zhou, Chun-Lei Shan, Yi Yang, Lian-Di Kan, Liu-Cheng Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Coronavirus COVID-19 SARS-CoV-2 Chinese herbal injection herb Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/29e4056335e644d5a39f7ce57fe519f8
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spelling	oai:doaj.org-article:29e4056335e644d5a39f7ce57fe519f82021-11-28T04:31:38ZChinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review2213-422010.1016/j.imr.2021.100778https://doaj.org/article/29e4056335e644d5a39f7ce57fe519f82021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213422021000652https://doaj.org/toc/2213-4220Background: The outbreak of Coronavirus disease 2019 (COVID-19) has caused more than 180 million infections and 3.9 million deaths. To date, emerging clinical evidence has shown the synergetic benefits of Chinese herbal injections in treating this contagious respiratory disease. This review aims to summarize and analyze the efficacy and safety of Chinese herbal injections in the therapy of COVID-19. Methods: The literature from 3 electronic databases, PubMed, CNKI, and Web of Science, were searched using the search terms “COVID-19”, “SARS-CoV-2”, “traditional Chinese medicine”, “herb”, “herbal”, and “injection”. Then the identified articles were comprehensively evaluated. Results: Limited data demonstrated that Chinese herbal injections could significantly improve the clinical outcomes of COVID-19 patients, especially in combination with conventional treatment strategies. The benefits of which were mainly associated with the relief of symptoms, prevention of secondary infection, regulation of inflammation and immune function. There was also evidence showing the inhibitory effects on SARS-CoV-2 replication in vitro. Nevertheless, available real-world data suggested the increased risk of adverse event. Furthermore, the defects of existing researches and the insights for discovering novel antiviral drugs were prospectively discussed. Conclusion: Evidence-based advances revealed that Chinese herbal injections such as XueBiJing injection and ShenMai injection, exerted potent effects against COVID-19. Further laboratory researches and clinical evaluation are needed to gather scientific evidence on the efficacy and safety.Xiao-Bin ZhuMeng GuoZhi-Hui ZhangLi-Hua SunLei LiuLi-Juan ZhouChun-Lei ShanYi YangLian-Di KanLiu-Cheng LiElsevierarticleCoronavirusCOVID-19SARS-CoV-2Chinese herbal injectionherbMiscellaneous systems and treatmentsRZ409.7-999ENIntegrative Medicine Research, Vol 10, Iss 4, Pp 100778- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coronavirus COVID-19 SARS-CoV-2 Chinese herbal injection herb Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Coronavirus COVID-19 SARS-CoV-2 Chinese herbal injection herb Miscellaneous systems and treatments RZ409.7-999 Xiao-Bin Zhu Meng Guo Zhi-Hui Zhang Li-Hua Sun Lei Liu Li-Juan Zhou Chun-Lei Shan Yi Yang Lian-Di Kan Liu-Cheng Li Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review
description	Background: The outbreak of Coronavirus disease 2019 (COVID-19) has caused more than 180 million infections and 3.9 million deaths. To date, emerging clinical evidence has shown the synergetic benefits of Chinese herbal injections in treating this contagious respiratory disease. This review aims to summarize and analyze the efficacy and safety of Chinese herbal injections in the therapy of COVID-19. Methods: The literature from 3 electronic databases, PubMed, CNKI, and Web of Science, were searched using the search terms “COVID-19”, “SARS-CoV-2”, “traditional Chinese medicine”, “herb”, “herbal”, and “injection”. Then the identified articles were comprehensively evaluated. Results: Limited data demonstrated that Chinese herbal injections could significantly improve the clinical outcomes of COVID-19 patients, especially in combination with conventional treatment strategies. The benefits of which were mainly associated with the relief of symptoms, prevention of secondary infection, regulation of inflammation and immune function. There was also evidence showing the inhibitory effects on SARS-CoV-2 replication in vitro. Nevertheless, available real-world data suggested the increased risk of adverse event. Furthermore, the defects of existing researches and the insights for discovering novel antiviral drugs were prospectively discussed. Conclusion: Evidence-based advances revealed that Chinese herbal injections such as XueBiJing injection and ShenMai injection, exerted potent effects against COVID-19. Further laboratory researches and clinical evaluation are needed to gather scientific evidence on the efficacy and safety.
format	article
author	Xiao-Bin Zhu Meng Guo Zhi-Hui Zhang Li-Hua Sun Lei Liu Li-Juan Zhou Chun-Lei Shan Yi Yang Lian-Di Kan Liu-Cheng Li
author_facet	Xiao-Bin Zhu Meng Guo Zhi-Hui Zhang Li-Hua Sun Lei Liu Li-Juan Zhou Chun-Lei Shan Yi Yang Lian-Di Kan Liu-Cheng Li
author_sort	Xiao-Bin Zhu
title	Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review
title_short	Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review
title_full	Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review
title_fullStr	Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review
title_full_unstemmed	Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review
title_sort	chinese herbal injections for coronavirus disease 2019 (covid-19): a narrative review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/29e4056335e644d5a39f7ce57fe519f8
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Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

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