Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.

Background: little researches have directly compared second-generation drug-eluting stents with each other or with bare-metal stents. Aim of the work: To compare between outcomes after implantation of bare-metal stents [BMS] and two kinds of 2nd generation drug eluting stents [DES] [Zotarolimus-Elut...

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Autor principal:	Khaled Alsayed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	bare metal zotarolimus eluting stents major adverse cardiac events in stent restenosis stent thrombosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/29e6dff8e4cd4a0fb946a5a897b58084
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spelling	oai:doaj.org-article:29e6dff8e4cd4a0fb946a5a897b580842021-12-02T14:02:00ZComparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.2636-41742682-378010.21608/ijma.2020.35338.1145https://doaj.org/article/29e6dff8e4cd4a0fb946a5a897b580842020-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_107606_8b9c1c1c3d00af5de46963c710e86f87.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: little researches have directly compared second-generation drug-eluting stents with each other or with bare-metal stents. Aim of the work: To compare between outcomes after implantation of bare-metal stents [BMS] and two kinds of 2nd generation drug eluting stents [DES] [Zotarolimus-Eluting Stents [ZES], and A Everolimus-Eluting Stents [EES]] in patients undergoing percutaneous coronary intervention. Patients and Methods: 160 Ischemic Heart Disease [IHD] patients undergoing PCI with 2nd generation DES implantation [80 ZES and 80 EES] were analyzed against 50 IHD patients undergoing PCI with BMS implantation. Each patients group received up to 6 [in BMS group] or 24 months [in ZES and EES groups] of clopidogrel therapy. The key efficacy endpoint was the 24 months major adverse cardiac event [MACE] [death, myocardial infarction, or target lesion revascularization], whereas stent thrombosis [ST] was the safety endpoint. Results: The MACE rate was lowest in EES [19%; χ2= 7.661], highest in BMS [41.7%; χ2 =7.661], and intermediate in ZES [28.2%; χ2= 7.661] group with significant P Value =0.002.The 2-year incidence of ST in the EES group [1.3%] was similar to that in the ZES-S group [2.2%], whereas it was lower in contrast with BMS [7.5%] groups, with significant P value= 0.004]. Conclusion: DES have more efficacy and safety than BMS as EES have lowest MACE and ST rate while BMS have the highest rate and ZES have intermediate rate while the three stent groups have similar rate of mortality at 2 years follow up.Khaled AlsayedAl-Azhar University, Faculty of Medicine (Damietta)articlebare metalzotarolimuseluting stentsmajor adverse cardiac eventsin stent restenosisstent thrombosisMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 4, Pp 786-792 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	bare metal zotarolimus eluting stents major adverse cardiac events in stent restenosis stent thrombosis Medicine (General) R5-920
spellingShingle	bare metal zotarolimus eluting stents major adverse cardiac events in stent restenosis stent thrombosis Medicine (General) R5-920 Khaled Alsayed Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
description	Background: little researches have directly compared second-generation drug-eluting stents with each other or with bare-metal stents. Aim of the work: To compare between outcomes after implantation of bare-metal stents [BMS] and two kinds of 2nd generation drug eluting stents [DES] [Zotarolimus-Eluting Stents [ZES], and A Everolimus-Eluting Stents [EES]] in patients undergoing percutaneous coronary intervention. Patients and Methods: 160 Ischemic Heart Disease [IHD] patients undergoing PCI with 2nd generation DES implantation [80 ZES and 80 EES] were analyzed against 50 IHD patients undergoing PCI with BMS implantation. Each patients group received up to 6 [in BMS group] or 24 months [in ZES and EES groups] of clopidogrel therapy. The key efficacy endpoint was the 24 months major adverse cardiac event [MACE] [death, myocardial infarction, or target lesion revascularization], whereas stent thrombosis [ST] was the safety endpoint. Results: The MACE rate was lowest in EES [19%; χ2= 7.661], highest in BMS [41.7%; χ2 =7.661], and intermediate in ZES [28.2%; χ2= 7.661] group with significant P Value =0.002.The 2-year incidence of ST in the EES group [1.3%] was similar to that in the ZES-S group [2.2%], whereas it was lower in contrast with BMS [7.5%] groups, with significant P value= 0.004]. Conclusion: DES have more efficacy and safety than BMS as EES have lowest MACE and ST rate while BMS have the highest rate and ZES have intermediate rate while the three stent groups have similar rate of mortality at 2 years follow up.
format	article
author	Khaled Alsayed
author_facet	Khaled Alsayed
author_sort	Khaled Alsayed
title	Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_short	Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_full	Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_fullStr	Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_full_unstemmed	Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.
title_sort	comparison between a bare–metal stents and drug eluting stents in patients undergoing percutaneous coronary intervention.
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/29e6dff8e4cd4a0fb946a5a897b58084
work_keys_str_mv	AT khaledalsayed comparisonbetweenabaremetalstentsanddrugelutingstentsinpatientsundergoingpercutaneouscoronaryintervention
_version_	1718392069453512704

Comparison between a Bare–Metal Stents and Drug Eluting Stents in patients undergoing Percutaneous Coronary Intervention.

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