pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

Targeting therapeutically-relevant proteins for degradation is an emerging paradigm in drug discovery. Here the authors describe a sensitive pulse SILAC mass spectrometry-based proteomics approach that reports global changes in protein stability following drug treatment in a single time point experi...

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Autores principales:	Jian An, Charles M. Ponthier, Ragna Sack, Jan Seebacher, Michael B. Stadler, Katherine A. Donovan, Eric S. Fischer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29e7aa9bcbbf457cab317eff9b4c1bbd
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spelling	oai:doaj.org-article:29e7aa9bcbbf457cab317eff9b4c1bbd2021-12-02T15:37:03ZpSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase10.1038/ncomms153982041-1723https://doaj.org/article/29e7aa9bcbbf457cab317eff9b4c1bbd2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15398https://doaj.org/toc/2041-1723Targeting therapeutically-relevant proteins for degradation is an emerging paradigm in drug discovery. Here the authors describe a sensitive pulse SILAC mass spectrometry-based proteomics approach that reports global changes in protein stability following drug treatment in a single time point experiment.Jian AnCharles M. PonthierRagna SackJan SeebacherMichael B. StadlerKatherine A. DonovanEric S. FischerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian An Charles M. Ponthier Ragna Sack Jan Seebacher Michael B. Stadler Katherine A. Donovan Eric S. Fischer pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
description	Targeting therapeutically-relevant proteins for degradation is an emerging paradigm in drug discovery. Here the authors describe a sensitive pulse SILAC mass spectrometry-based proteomics approach that reports global changes in protein stability following drug treatment in a single time point experiment.
format	article
author	Jian An Charles M. Ponthier Ragna Sack Jan Seebacher Michael B. Stadler Katherine A. Donovan Eric S. Fischer
author_facet	Jian An Charles M. Ponthier Ragna Sack Jan Seebacher Michael B. Stadler Katherine A. Donovan Eric S. Fischer
author_sort	Jian An
title	pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
title_short	pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
title_full	pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
title_fullStr	pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
title_full_unstemmed	pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase
title_sort	psilac mass spectrometry reveals zfp91 as imid-dependent substrate of the crl4crbn ubiquitin ligase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29e7aa9bcbbf457cab317eff9b4c1bbd
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pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

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