Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway

Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway

The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.

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Autores principales: Fumiaki Ando, Eisei Sohara, Tetsuji Morimoto, Naofumi Yui, Naohiro Nomura, Eriko Kikuchi, Daiei Takahashi, Takayasu Mori, Alain Vandewalle, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Shinichi Uchida
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/29e7b2aadd534db090339dd9c18e6a53
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spelling oai:doaj.org-article:29e7b2aadd534db090339dd9c18e6a532021-12-02T15:35:23ZWnt5a induces renal AQP2 expression by activating calcineurin signalling pathway10.1038/ncomms136362041-1723https://doaj.org/article/29e7b2aadd534db090339dd9c18e6a532016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13636https://doaj.org/toc/2041-1723The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.Fumiaki AndoEisei SoharaTetsuji MorimotoNaofumi YuiNaohiro NomuraEriko KikuchiDaiei TakahashiTakayasu MoriAlain VandewalleTatemitsu RaiSei SasakiYoshiaki KondoShinichi UchidaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fumiaki Ando
Eisei Sohara
Tetsuji Morimoto
Naofumi Yui
Naohiro Nomura
Eriko Kikuchi
Daiei Takahashi
Takayasu Mori
Alain Vandewalle
Tatemitsu Rai
Sei Sasaki
Yoshiaki Kondo
Shinichi Uchida
Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
description The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.
format article
author Fumiaki Ando
Eisei Sohara
Tetsuji Morimoto
Naofumi Yui
Naohiro Nomura
Eriko Kikuchi
Daiei Takahashi
Takayasu Mori
Alain Vandewalle
Tatemitsu Rai
Sei Sasaki
Yoshiaki Kondo
Shinichi Uchida
author_facet Fumiaki Ando
Eisei Sohara
Tetsuji Morimoto
Naofumi Yui
Naohiro Nomura
Eriko Kikuchi
Daiei Takahashi
Takayasu Mori
Alain Vandewalle
Tatemitsu Rai
Sei Sasaki
Yoshiaki Kondo
Shinichi Uchida
author_sort Fumiaki Ando
title Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
title_short Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
title_full Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
title_fullStr Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
title_full_unstemmed Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
title_sort wnt5a induces renal aqp2 expression by activating calcineurin signalling pathway
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/29e7b2aadd534db090339dd9c18e6a53
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