Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis

Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karina Rossi Bonfiglioli, Licia Maria Henrique da Mota, Ana Cristina de Medeiros Ribeiro, Adriana Maria Kakehasi, Ieda Maria Magalhães Laurindo, Rina Dalva Neubarth Giorgi, Angela Luzia Branco Pinto Duarte, Ana Paula Monteiro Gomides Reis, Mariana Peixoto Guimarães Ubirajara e Silva de Souza, Claiton Viegas Brenol, Geraldo da Rocha Castelar Pinheiro, Cleandro Pires de Albuquerque, Charlles Heldan de Moura Castro, Gustavo Luiz Behrens Pinto, Jose Fernando Verztman, Luciana Feitosa Muniz, Manoel Barros Bertolo, Maria Raquel da Costa Pinto, Paulo Louzada Júnior, Vitor Alves Cruz, Ivanio Alves Pereira, Max Vitor Carioca de Freitas, Bóris Afonso Cruz, Eduardo Paiva, Odirlei Monticielo, José Roberto Provenza, Ricardo Machado Xavier
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Diseases of the musculoskeletal system RC925-935 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/29eb58b890394fa49f3e3b5912989336
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:29eb58b890394fa49f3e3b5912989336
record_format	dspace
spelling	oai:doaj.org-article:29eb58b890394fa49f3e3b59129893362021-11-28T12:23:45ZRecommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis10.1186/s42358-021-00228-x2523-3106https://doaj.org/article/29eb58b890394fa49f3e3b59129893362021-11-01T00:00:00Zhttps://doi.org/10.1186/s42358-021-00228-xhttps://doaj.org/toc/2523-3106Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.Karina Rossi BonfiglioliLicia Maria Henrique da MotaAna Cristina de Medeiros RibeiroAdriana Maria KakehasiIeda Maria Magalhães LaurindoRina Dalva Neubarth GiorgiAngela Luzia Branco Pinto DuarteAna Paula Monteiro Gomides ReisMariana Peixoto Guimarães Ubirajara e Silva de SouzaClaiton Viegas BrenolGeraldo da Rocha Castelar PinheiroCleandro Pires de AlbuquerqueCharlles Heldan de Moura CastroGustavo Luiz Behrens PintoJose Fernando VerztmanLuciana Feitosa MunizManoel Barros BertoloMaria Raquel da Costa PintoPaulo Louzada JúniorVitor Alves CruzIvanio Alves PereiraMax Vitor Carioca de FreitasBóris Afonso CruzEduardo PaivaOdirlei MonticieloJosé Roberto ProvenzaRicardo Machado XavierBMCarticleDiseases of the musculoskeletal systemRC925-935Immunologic diseases. AllergyRC581-607ENAdvances in Rheumatology, Vol 61, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935 Immunologic diseases. Allergy RC581-607
spellingShingle	Diseases of the musculoskeletal system RC925-935 Immunologic diseases. Allergy RC581-607 Karina Rossi Bonfiglioli Licia Maria Henrique da Mota Ana Cristina de Medeiros Ribeiro Adriana Maria Kakehasi Ieda Maria Magalhães Laurindo Rina Dalva Neubarth Giorgi Angela Luzia Branco Pinto Duarte Ana Paula Monteiro Gomides Reis Mariana Peixoto Guimarães Ubirajara e Silva de Souza Claiton Viegas Brenol Geraldo da Rocha Castelar Pinheiro Cleandro Pires de Albuquerque Charlles Heldan de Moura Castro Gustavo Luiz Behrens Pinto Jose Fernando Verztman Luciana Feitosa Muniz Manoel Barros Bertolo Maria Raquel da Costa Pinto Paulo Louzada Júnior Vitor Alves Cruz Ivanio Alves Pereira Max Vitor Carioca de Freitas Bóris Afonso Cruz Eduardo Paiva Odirlei Monticielo José Roberto Provenza Ricardo Machado Xavier Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
description	Abstract Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.
format	article
author	Karina Rossi Bonfiglioli Licia Maria Henrique da Mota Ana Cristina de Medeiros Ribeiro Adriana Maria Kakehasi Ieda Maria Magalhães Laurindo Rina Dalva Neubarth Giorgi Angela Luzia Branco Pinto Duarte Ana Paula Monteiro Gomides Reis Mariana Peixoto Guimarães Ubirajara e Silva de Souza Claiton Viegas Brenol Geraldo da Rocha Castelar Pinheiro Cleandro Pires de Albuquerque Charlles Heldan de Moura Castro Gustavo Luiz Behrens Pinto Jose Fernando Verztman Luciana Feitosa Muniz Manoel Barros Bertolo Maria Raquel da Costa Pinto Paulo Louzada Júnior Vitor Alves Cruz Ivanio Alves Pereira Max Vitor Carioca de Freitas Bóris Afonso Cruz Eduardo Paiva Odirlei Monticielo José Roberto Provenza Ricardo Machado Xavier
author_facet	Karina Rossi Bonfiglioli Licia Maria Henrique da Mota Ana Cristina de Medeiros Ribeiro Adriana Maria Kakehasi Ieda Maria Magalhães Laurindo Rina Dalva Neubarth Giorgi Angela Luzia Branco Pinto Duarte Ana Paula Monteiro Gomides Reis Mariana Peixoto Guimarães Ubirajara e Silva de Souza Claiton Viegas Brenol Geraldo da Rocha Castelar Pinheiro Cleandro Pires de Albuquerque Charlles Heldan de Moura Castro Gustavo Luiz Behrens Pinto Jose Fernando Verztman Luciana Feitosa Muniz Manoel Barros Bertolo Maria Raquel da Costa Pinto Paulo Louzada Júnior Vitor Alves Cruz Ivanio Alves Pereira Max Vitor Carioca de Freitas Bóris Afonso Cruz Eduardo Paiva Odirlei Monticielo José Roberto Provenza Ricardo Machado Xavier
author_sort	Karina Rossi Bonfiglioli
title	Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
title_short	Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
title_full	Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
title_fullStr	Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
title_full_unstemmed	Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis
title_sort	recommendations of the brazilian society of rheumatology for the use of jak inhibitors in the management of rheumatoid arthritis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/29eb58b890394fa49f3e3b5912989336
work_keys_str_mv	AT karinarossibonfiglioli recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT liciamariahenriquedamota recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT anacristinademedeirosribeiro recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT adrianamariakakehasi recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT iedamariamagalhaeslaurindo recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT rinadalvaneubarthgiorgi recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT angelaluziabrancopintoduarte recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT anapaulamonteirogomidesreis recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT marianapeixotoguimaraesubirajaraesilvadesouza recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT claitonviegasbrenol recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT geraldodarochacastelarpinheiro recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT cleandropiresdealbuquerque recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT charllesheldandemouracastro recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT gustavoluizbehrenspinto recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT josefernandoverztman recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT lucianafeitosamuniz recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT manoelbarrosbertolo recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT mariaraqueldacostapinto recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT paulolouzadajunior recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT vitoralvescruz recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT ivanioalvespereira recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT maxvitorcariocadefreitas recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT borisafonsocruz recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT eduardopaiva recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT odirleimonticielo recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT joserobertoprovenza recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis AT ricardomachadoxavier recommendationsofthebraziliansocietyofrheumatologyfortheuseofjakinhibitorsinthemanagementofrheumatoidarthritis
_version_	1718408002691661824

Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis

Ejemplares similares