Major depressive disorder: mechanism-based prescribing for personalized medicine

Philip F Saltiel,1 Daniel I Silvershein2 1Department of Psychiatry, New York University School of Medicine/Langone Medical Center New York University Behavioral Health Programs, New York University Pearl Barlow Center for Memory Evaluation and Treatment, New York, NY, USA; 2Department of Medicine,...

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Autores principales:	Saltiel PF, Silvershein DI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/29eb824b2afb4da09a4d53c473f72fcb
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spelling	oai:doaj.org-article:29eb824b2afb4da09a4d53c473f72fcb2021-12-02T08:46:57ZMajor depressive disorder: mechanism-based prescribing for personalized medicine1178-2021https://doaj.org/article/29eb824b2afb4da09a4d53c473f72fcb2015-03-01T00:00:00Zhttp://www.dovepress.com/major-depressive-disorder-mechanism-based-prescribing-for-personalized-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Philip F Saltiel,1 Daniel I Silvershein2 1Department of Psychiatry, New York University School of Medicine/Langone Medical Center New York University Behavioral Health Programs, New York University Pearl Barlow Center for Memory Evaluation and Treatment, New York, NY, USA; 2Department of Medicine, New York University School of Medicine/Langone Medical Center, New York, NY, USA Abstract: Individual patients with depression present with unique symptom clusters – before, during, and even after treatment. The prevalence of persistent, unresolved symptoms and their contribution to patient functioning and disease progression emphasize the importance of finding the right treatment choice at the onset and the utility of switching medications based on suboptimal responses. Our primary goal as clinicians is to improve patient function and quality of life. In fact, feelings of well-being and the return to premorbid levels of functioning are frequently rated by patients as being more important than symptom relief. However, functional improvements often lag behind resolution of mood, attributed in large part to persistent and functionally impairing symptoms – namely, fatigue, sleep/wake disturbance, and cognitive dysfunction. Thus, patient outcomes can be optimized by deconstructing each patient’s depressive profile to its component symptoms and specifically targeting those domains that differentially limit patient function. This article will provide an evidence-based framework within which clinicians may tailor pharmacotherapy to patient symptomatology for improved treatment outcomes. Keywords: MDD, tailored pharmacotherapy, patient-specific profile, individualized pharmacotherapySaltiel PFSilvershein DIDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 875-888 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Saltiel PF Silvershein DI Major depressive disorder: mechanism-based prescribing for personalized medicine
description	Philip F Saltiel,1 Daniel I Silvershein2 1Department of Psychiatry, New York University School of Medicine/Langone Medical Center New York University Behavioral Health Programs, New York University Pearl Barlow Center for Memory Evaluation and Treatment, New York, NY, USA; 2Department of Medicine, New York University School of Medicine/Langone Medical Center, New York, NY, USA Abstract: Individual patients with depression present with unique symptom clusters – before, during, and even after treatment. The prevalence of persistent, unresolved symptoms and their contribution to patient functioning and disease progression emphasize the importance of finding the right treatment choice at the onset and the utility of switching medications based on suboptimal responses. Our primary goal as clinicians is to improve patient function and quality of life. In fact, feelings of well-being and the return to premorbid levels of functioning are frequently rated by patients as being more important than symptom relief. However, functional improvements often lag behind resolution of mood, attributed in large part to persistent and functionally impairing symptoms – namely, fatigue, sleep/wake disturbance, and cognitive dysfunction. Thus, patient outcomes can be optimized by deconstructing each patient’s depressive profile to its component symptoms and specifically targeting those domains that differentially limit patient function. This article will provide an evidence-based framework within which clinicians may tailor pharmacotherapy to patient symptomatology for improved treatment outcomes. Keywords: MDD, tailored pharmacotherapy, patient-specific profile, individualized pharmacotherapy
format	article
author	Saltiel PF Silvershein DI
author_facet	Saltiel PF Silvershein DI
author_sort	Saltiel PF
title	Major depressive disorder: mechanism-based prescribing for personalized medicine
title_short	Major depressive disorder: mechanism-based prescribing for personalized medicine
title_full	Major depressive disorder: mechanism-based prescribing for personalized medicine
title_fullStr	Major depressive disorder: mechanism-based prescribing for personalized medicine
title_full_unstemmed	Major depressive disorder: mechanism-based prescribing for personalized medicine
title_sort	major depressive disorder: mechanism-based prescribing for personalized medicine
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/29eb824b2afb4da09a4d53c473f72fcb
work_keys_str_mv	AT saltielpf majordepressivedisordermechanismbasedprescribingforpersonalizedmedicine AT silversheindi majordepressivedisordermechanismbasedprescribingforpersonalizedmedicine
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Major depressive disorder: mechanism-based prescribing for personalized medicine

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