White matter microstructural changes are related to cognitive dysfunction in essential tremor

Abstract Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julián Benito-León, Virginia Mato-Abad, Elan D. Louis, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ángela Domingo-Santos, Luis Collado, Juan Pablo Romero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29ef8d29519046ce9c1d45f0e8101a2d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:29ef8d29519046ce9c1d45f0e8101a2d
record_format	dspace
spelling	oai:doaj.org-article:29ef8d29519046ce9c1d45f0e8101a2d2021-12-02T12:31:52ZWhite matter microstructural changes are related to cognitive dysfunction in essential tremor10.1038/s41598-017-02596-12045-2322https://doaj.org/article/29ef8d29519046ce9c1d45f0e8101a2d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02596-1https://doaj.org/toc/2045-2322Abstract Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined. ET patients demonstrated increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fasciculus, bilateral fornix (cres)/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs of internal capsule, bilateral retrolenticular region part of internal capsule, and left posterior thalamic radiation. Except for the genu of the corpus callosum, an increase in AD values was also found in these same tracts. Furthermore, increased MD and AD values in different white matter areas was negatively correlated with performance on language and verbal memory and positively with visuospatial ability. These correlations suggest that white matter changes might be involved in the pathogenesis of cognitive deficits in ET.Julián Benito-LeónVirginia Mato-AbadElan D. LouisJuan Antonio Hernández-TamamesJuan Álvarez-LineraFélix Bermejo-ParejaÁngela Domingo-SantosLuis ColladoJuan Pablo RomeroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julián Benito-León Virginia Mato-Abad Elan D. Louis Juan Antonio Hernández-Tamames Juan Álvarez-Linera Félix Bermejo-Pareja Ángela Domingo-Santos Luis Collado Juan Pablo Romero White matter microstructural changes are related to cognitive dysfunction in essential tremor
description	Abstract Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined. ET patients demonstrated increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fasciculus, bilateral fornix (cres)/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs of internal capsule, bilateral retrolenticular region part of internal capsule, and left posterior thalamic radiation. Except for the genu of the corpus callosum, an increase in AD values was also found in these same tracts. Furthermore, increased MD and AD values in different white matter areas was negatively correlated with performance on language and verbal memory and positively with visuospatial ability. These correlations suggest that white matter changes might be involved in the pathogenesis of cognitive deficits in ET.
format	article
author	Julián Benito-León Virginia Mato-Abad Elan D. Louis Juan Antonio Hernández-Tamames Juan Álvarez-Linera Félix Bermejo-Pareja Ángela Domingo-Santos Luis Collado Juan Pablo Romero
author_facet	Julián Benito-León Virginia Mato-Abad Elan D. Louis Juan Antonio Hernández-Tamames Juan Álvarez-Linera Félix Bermejo-Pareja Ángela Domingo-Santos Luis Collado Juan Pablo Romero
author_sort	Julián Benito-León
title	White matter microstructural changes are related to cognitive dysfunction in essential tremor
title_short	White matter microstructural changes are related to cognitive dysfunction in essential tremor
title_full	White matter microstructural changes are related to cognitive dysfunction in essential tremor
title_fullStr	White matter microstructural changes are related to cognitive dysfunction in essential tremor
title_full_unstemmed	White matter microstructural changes are related to cognitive dysfunction in essential tremor
title_sort	white matter microstructural changes are related to cognitive dysfunction in essential tremor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/29ef8d29519046ce9c1d45f0e8101a2d
work_keys_str_mv	AT julianbenitoleon whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT virginiamatoabad whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT elandlouis whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT juanantoniohernandeztamames whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT juanalvarezlinera whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT felixbermejopareja whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT angeladomingosantos whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT luiscollado whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor AT juanpabloromero whitemattermicrostructuralchangesarerelatedtocognitivedysfunctioninessentialtremor
_version_	1718394206834130944

White matter microstructural changes are related to cognitive dysfunction in essential tremor

Ejemplares similares