Properties of repression condensates in living Ciona embryos

While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of Hes repressors, with the Groucho/TLE corepressor, ob...

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Auteurs principaux:	Nicholas Treen, Shunsuke F. Shimobayashi, Jorine Eeftens, Clifford P. Brangwynne, Michael Levine
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc
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id	oai:doaj.org-article:29f07ca6d62e4813bc5ededc4c809dcc
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spelling	oai:doaj.org-article:29f07ca6d62e4813bc5ededc4c809dcc2021-12-02T13:34:49ZProperties of repression condensates in living Ciona embryos10.1038/s41467-021-21606-52041-1723https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21606-5https://doaj.org/toc/2041-1723While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of Hes repressors, with the Groucho/TLE corepressor, observing that the Hes.a/Gro puncta have the properties of viscous liquid droplets that undergo limited fusion events due to association with DNA.Nicholas TreenShunsuke F. ShimobayashiJorine EeftensClifford P. BrangwynneMichael LevineNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas Treen Shunsuke F. Shimobayashi Jorine Eeftens Clifford P. Brangwynne Michael Levine Properties of repression condensates in living Ciona embryos
description	While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of Hes repressors, with the Groucho/TLE corepressor, observing that the Hes.a/Gro puncta have the properties of viscous liquid droplets that undergo limited fusion events due to association with DNA.
format	article
author	Nicholas Treen Shunsuke F. Shimobayashi Jorine Eeftens Clifford P. Brangwynne Michael Levine
author_facet	Nicholas Treen Shunsuke F. Shimobayashi Jorine Eeftens Clifford P. Brangwynne Michael Levine
author_sort	Nicholas Treen
title	Properties of repression condensates in living Ciona embryos
title_short	Properties of repression condensates in living Ciona embryos
title_full	Properties of repression condensates in living Ciona embryos
title_fullStr	Properties of repression condensates in living Ciona embryos
title_full_unstemmed	Properties of repression condensates in living Ciona embryos
title_sort	properties of repression condensates in living ciona embryos
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc
work_keys_str_mv	AT nicholastreen propertiesofrepressioncondensatesinlivingcionaembryos AT shunsukefshimobayashi propertiesofrepressioncondensatesinlivingcionaembryos AT jorineeeftens propertiesofrepressioncondensatesinlivingcionaembryos AT cliffordpbrangwynne propertiesofrepressioncondensatesinlivingcionaembryos AT michaellevine propertiesofrepressioncondensatesinlivingcionaembryos
_version_	1718392724168638464

Properties of repression condensates in living Ciona embryos

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