Properties of repression condensates in living Ciona embryos
While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of Hes repressors, with the Groucho/TLE corepressor, ob...
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Nature Portfolio
2021
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oai:doaj.org-article:29f07ca6d62e4813bc5ededc4c809dcc2021-12-02T13:34:49ZProperties of repression condensates in living Ciona embryos10.1038/s41467-021-21606-52041-1723https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21606-5https://doaj.org/toc/2041-1723While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of Hes repressors, with the Groucho/TLE corepressor, observing that the Hes.a/Gro puncta have the properties of viscous liquid droplets that undergo limited fusion events due to association with DNA.Nicholas TreenShunsuke F. ShimobayashiJorine EeftensClifford P. BrangwynneMichael LevineNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
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Science Q Nicholas Treen Shunsuke F. Shimobayashi Jorine Eeftens Clifford P. Brangwynne Michael Levine Properties of repression condensates in living Ciona embryos |
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While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of Hes repressors, with the Groucho/TLE corepressor, observing that the Hes.a/Gro puncta have the properties of viscous liquid droplets that undergo limited fusion events due to association with DNA. |
format |
article |
author |
Nicholas Treen Shunsuke F. Shimobayashi Jorine Eeftens Clifford P. Brangwynne Michael Levine |
author_facet |
Nicholas Treen Shunsuke F. Shimobayashi Jorine Eeftens Clifford P. Brangwynne Michael Levine |
author_sort |
Nicholas Treen |
title |
Properties of repression condensates in living Ciona embryos |
title_short |
Properties of repression condensates in living Ciona embryos |
title_full |
Properties of repression condensates in living Ciona embryos |
title_fullStr |
Properties of repression condensates in living Ciona embryos |
title_full_unstemmed |
Properties of repression condensates in living Ciona embryos |
title_sort |
properties of repression condensates in living ciona embryos |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc |
work_keys_str_mv |
AT nicholastreen propertiesofrepressioncondensatesinlivingcionaembryos AT shunsukefshimobayashi propertiesofrepressioncondensatesinlivingcionaembryos AT jorineeeftens propertiesofrepressioncondensatesinlivingcionaembryos AT cliffordpbrangwynne propertiesofrepressioncondensatesinlivingcionaembryos AT michaellevine propertiesofrepressioncondensatesinlivingcionaembryos |
_version_ |
1718392724168638464 |