Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?

<h4>Background</h4>Low circulating vitamin D levels have been suggested to potentially contribute to acute complications in critically ill patients. However, in patients with acute kidney injury (AKI), whether vitamin D deficiency occurs and is a potential contributor to worse early outc...

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Autores principales:	Lingyun Lai, Jing Qian, Yanjiao Yang, Qionghong Xie, Huaizhou You, Ying Zhou, Shuai Ma, Chuanming Hao, Yong Gu, Feng Ding
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29f2d3f8ee6e4432a81a16249456050b
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spelling	oai:doaj.org-article:29f2d3f8ee6e4432a81a16249456050b2021-11-18T07:44:29ZIs the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?1932-620310.1371/journal.pone.0064964https://doaj.org/article/29f2d3f8ee6e4432a81a16249456050b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717679/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Low circulating vitamin D levels have been suggested to potentially contribute to acute complications in critically ill patients. However, in patients with acute kidney injury (AKI), whether vitamin D deficiency occurs and is a potential contributor to worse early outcomes at the time of AKI diagnosis remains unclear.<h4>Methodology/principal findings</h4>Two hundred patients with AKI were enrolled in our study. Healthy subjects and critically ill patients without AKI served as controls. Serum vitamin D concentrations were measured in the three groups. The patients with AKI were followed up for 90 days and grouped according to median serum vitamin D concentrations. In addition, vitamin D receptor polymorphisms (BsmI and FokI) were measured in these patients; they were also followed up for 90 days and grouped according to vitamin D receptor gene mutations. Low serum 1,25-dihydroxyvitamin D levels (59.56±53.00 pmol/L) were detected in patients with AKI and decreased with increasing severity of AKI. There were no significant findings with respect to 25-hydroxyvitamin D. The 90-day survival curves of individuals with high vitamin D concentrations showed no significant differences compared with the curves of individuals with low concentrations. The survival curves of patients with BB/Bb or FF/Ff genotypes also showed no significant differences compared with patients with bb or ff genotypes. In Cox regression analysis, the vitamin D status in patients with AKI was not an independent prognostic factor as adjusted by age, sex, Sequential Organ Failure Assessment score, or vitamin D receptor polymorphisms.<h4>Conclusions/significance</h4>Patients with AKI manifested a marked decrease in the 1,25-dihydroxyvitamin D level at the time of AKI diagnosis, and the degree of 1,25-dihydroxyvitamin D deficiency increased with the severity of AKI. No association between the serum vitamin D level at the time of AKI diagnosis and 90-day all-cause mortality was found in patients with AKI.Lingyun LaiJing QianYanjiao YangQionghong XieHuaizhou YouYing ZhouShuai MaChuanming HaoYong GuFeng DingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64964 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingyun Lai Jing Qian Yanjiao Yang Qionghong Xie Huaizhou You Ying Zhou Shuai Ma Chuanming Hao Yong Gu Feng Ding Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
description	<h4>Background</h4>Low circulating vitamin D levels have been suggested to potentially contribute to acute complications in critically ill patients. However, in patients with acute kidney injury (AKI), whether vitamin D deficiency occurs and is a potential contributor to worse early outcomes at the time of AKI diagnosis remains unclear.<h4>Methodology/principal findings</h4>Two hundred patients with AKI were enrolled in our study. Healthy subjects and critically ill patients without AKI served as controls. Serum vitamin D concentrations were measured in the three groups. The patients with AKI were followed up for 90 days and grouped according to median serum vitamin D concentrations. In addition, vitamin D receptor polymorphisms (BsmI and FokI) were measured in these patients; they were also followed up for 90 days and grouped according to vitamin D receptor gene mutations. Low serum 1,25-dihydroxyvitamin D levels (59.56±53.00 pmol/L) were detected in patients with AKI and decreased with increasing severity of AKI. There were no significant findings with respect to 25-hydroxyvitamin D. The 90-day survival curves of individuals with high vitamin D concentrations showed no significant differences compared with the curves of individuals with low concentrations. The survival curves of patients with BB/Bb or FF/Ff genotypes also showed no significant differences compared with patients with bb or ff genotypes. In Cox regression analysis, the vitamin D status in patients with AKI was not an independent prognostic factor as adjusted by age, sex, Sequential Organ Failure Assessment score, or vitamin D receptor polymorphisms.<h4>Conclusions/significance</h4>Patients with AKI manifested a marked decrease in the 1,25-dihydroxyvitamin D level at the time of AKI diagnosis, and the degree of 1,25-dihydroxyvitamin D deficiency increased with the severity of AKI. No association between the serum vitamin D level at the time of AKI diagnosis and 90-day all-cause mortality was found in patients with AKI.
format	article
author	Lingyun Lai Jing Qian Yanjiao Yang Qionghong Xie Huaizhou You Ying Zhou Shuai Ma Chuanming Hao Yong Gu Feng Ding
author_facet	Lingyun Lai Jing Qian Yanjiao Yang Qionghong Xie Huaizhou You Ying Zhou Shuai Ma Chuanming Hao Yong Gu Feng Ding
author_sort	Lingyun Lai
title	Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
title_short	Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
title_full	Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
title_fullStr	Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
title_full_unstemmed	Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
title_sort	is the serum vitamin d level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/29f2d3f8ee6e4432a81a16249456050b
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Is the serum vitamin D level at the time of hospital-acquired acute kidney injury diagnosis associated with prognosis?

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