Targeted NGF siRNA delivery attenuates sympathetic nerve sprouting and deteriorates cardiac dysfunction in rats with myocardial infarction.

Targeted NGF siRNA delivery attenuates sympathetic nerve sprouting and deteriorates cardiac dysfunction in rats with myocardial infarction.

Nerve growth factor (NGF) is involved in nerve sprouting, hyper-innervation, angiogenesis, anti-apoptosis, and preservation of cardiac function after myocardial infarction (MI). Positively modulating NGF expression may represent a novel pharmacological strategy to improve post-infarction prognosis....

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Bibliographic Details
Main Authors: Hesheng Hu, Yongli Xuan, Ye Wang, Mei Xue, Fei Suo, Xiaolu Li, Wenjuan Cheng, Xinran Li, Jie Yin, Ju Liu, Suhua Yan
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/29f46f7a47d94defabd9afd4e3e872c0
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