Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases

Summary: Allergic diseases are closely related to degranulation and release of histamine and difficult to diagnose because non-allergic diseases also exhibit the same clinical symptoms as allergy. Here, we report direct, rapid, and ultrasensitive detection of histamine using low-frequency molecular...

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Autores principales:	Haogang Zhu, Shuo Liu, Zijing Guo, Kun Yan, Jiancang Shen, Zhiyong Zhang, Jian Chen, Yachong Guo, Lizhe Liu, Xinglong Wu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biochemistry Engineering Surface sensing Science Q
Acceso en línea:	https://doaj.org/article/29f824d88144490d8d0b4840b69febd7
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spelling	oai:doaj.org-article:29f824d88144490d8d0b4840b69febd72021-11-20T05:10:59ZStrong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases2589-004210.1016/j.isci.2021.103384https://doaj.org/article/29f824d88144490d8d0b4840b69febd72021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013559https://doaj.org/toc/2589-0042Summary: Allergic diseases are closely related to degranulation and release of histamine and difficult to diagnose because non-allergic diseases also exhibit the same clinical symptoms as allergy. Here, we report direct, rapid, and ultrasensitive detection of histamine using low-frequency molecular torsion Raman spectroscopy. We show that the low-frequency (<200 cm−1) Raman spectral intensities are stronger by one order of magnitude than those of the high-frequency Raman ones. Density functional theory calculation and nuclear magnetic resonance spectroscopy identify the strong spectral feature to be from torsions of carbon-carbon single bonds, which produce large variations of the polarizability densities in the imidazole ring and ethyl amino side chain. Using an omniphobic substrate and surface plasmonic effect of Au@SiO2 nanoparticles, the detection limit (signal-noise ratio >3) of histamine reaches 10−8 g/L in water and 10−6 g/L in serum. This scheme thus opens new lines of inquiry regarding the clinical diagnosis of allergic diseases.Haogang ZhuShuo LiuZijing GuoKun YanJiancang ShenZhiyong ZhangJian ChenYachong GuoLizhe LiuXinglong WuElsevierarticleBiochemistryEngineeringSurface sensingScienceQENiScience, Vol 24, Iss 11, Pp 103384- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biochemistry Engineering Surface sensing Science Q
spellingShingle	Biochemistry Engineering Surface sensing Science Q Haogang Zhu Shuo Liu Zijing Guo Kun Yan Jiancang Shen Zhiyong Zhang Jian Chen Yachong Guo Lizhe Liu Xinglong Wu Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
description	Summary: Allergic diseases are closely related to degranulation and release of histamine and difficult to diagnose because non-allergic diseases also exhibit the same clinical symptoms as allergy. Here, we report direct, rapid, and ultrasensitive detection of histamine using low-frequency molecular torsion Raman spectroscopy. We show that the low-frequency (<200 cm−1) Raman spectral intensities are stronger by one order of magnitude than those of the high-frequency Raman ones. Density functional theory calculation and nuclear magnetic resonance spectroscopy identify the strong spectral feature to be from torsions of carbon-carbon single bonds, which produce large variations of the polarizability densities in the imidazole ring and ethyl amino side chain. Using an omniphobic substrate and surface plasmonic effect of Au@SiO2 nanoparticles, the detection limit (signal-noise ratio >3) of histamine reaches 10−8 g/L in water and 10−6 g/L in serum. This scheme thus opens new lines of inquiry regarding the clinical diagnosis of allergic diseases.
format	article
author	Haogang Zhu Shuo Liu Zijing Guo Kun Yan Jiancang Shen Zhiyong Zhang Jian Chen Yachong Guo Lizhe Liu Xinglong Wu
author_facet	Haogang Zhu Shuo Liu Zijing Guo Kun Yan Jiancang Shen Zhiyong Zhang Jian Chen Yachong Guo Lizhe Liu Xinglong Wu
author_sort	Haogang Zhu
title	Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
title_short	Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
title_full	Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
title_fullStr	Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
title_full_unstemmed	Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
title_sort	strong histamine torsion raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/29f824d88144490d8d0b4840b69febd7
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Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases

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