Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study

Abstract We used a retrospective study design to evaluated the predictive value of red cell distribution width (RDW) for drug-induced liver injury (DILI) severity in Chinese patients with liver biopsy to assist with early DILI management. We included 164 DILI patients with complete laboratory inform...

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Autores principales:	Xu Li, Hongqin Xu, Pujun Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29ffb46996a347d29eaedc9be58c49f6
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spelling	oai:doaj.org-article:29ffb46996a347d29eaedc9be58c49f62021-12-02T14:12:10ZIncreased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study10.1038/s41598-020-80116-42045-2322https://doaj.org/article/29ffb46996a347d29eaedc9be58c49f62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80116-4https://doaj.org/toc/2045-2322Abstract We used a retrospective study design to evaluated the predictive value of red cell distribution width (RDW) for drug-induced liver injury (DILI) severity in Chinese patients with liver biopsy to assist with early DILI management. We included 164 DILI patients with complete laboratory information and medical history. We compared outcomes of 36 patients with severe DILI with outcomes of a control group of 128 patients with mild-to-moderate DILI. Multivariate analyses of risk factors for severe liver injury in Chinese patients with DILI revealed an estimated adjusted odds ratio (AOR) (95% CI) of 4.938 (1.088–22.412) in patients with drinking. Risk for serious liver injury was also increased significantly in patients with dyslipidemia [AOR (95% CI) 3.926 (1.282–12.026)], higher serum total bile acid (TBA) levels [AOR (95% CI) 1.014 (1.009–1.020)] and higher RDW [AOR (95% CI) 1.582 (1.261–1.986)]. The result for area under the curve of 0.905 for TBA levels indicated this variable had high diagnostic performance for predicting DILI severity. Based on an area under the curve value of 0.855, RDW also had superior diagnostic performance in prediction of DILI severity. This performance was not significantly different compared with TBA and was superior compared with other variables, which had area under values ranging from poor to failure (0.527–0.714).The risk for severe DILI was associated with drinking, dyslipidemia, higher TBA levels and RDW values. This study found that RDW and TBA levels were predictors of DILI severity in Chinese patients.Xu LiHongqin XuPujun GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xu Li Hongqin Xu Pujun Gao Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
description	Abstract We used a retrospective study design to evaluated the predictive value of red cell distribution width (RDW) for drug-induced liver injury (DILI) severity in Chinese patients with liver biopsy to assist with early DILI management. We included 164 DILI patients with complete laboratory information and medical history. We compared outcomes of 36 patients with severe DILI with outcomes of a control group of 128 patients with mild-to-moderate DILI. Multivariate analyses of risk factors for severe liver injury in Chinese patients with DILI revealed an estimated adjusted odds ratio (AOR) (95% CI) of 4.938 (1.088–22.412) in patients with drinking. Risk for serious liver injury was also increased significantly in patients with dyslipidemia [AOR (95% CI) 3.926 (1.282–12.026)], higher serum total bile acid (TBA) levels [AOR (95% CI) 1.014 (1.009–1.020)] and higher RDW [AOR (95% CI) 1.582 (1.261–1.986)]. The result for area under the curve of 0.905 for TBA levels indicated this variable had high diagnostic performance for predicting DILI severity. Based on an area under the curve value of 0.855, RDW also had superior diagnostic performance in prediction of DILI severity. This performance was not significantly different compared with TBA and was superior compared with other variables, which had area under values ranging from poor to failure (0.527–0.714).The risk for severe DILI was associated with drinking, dyslipidemia, higher TBA levels and RDW values. This study found that RDW and TBA levels were predictors of DILI severity in Chinese patients.
format	article
author	Xu Li Hongqin Xu Pujun Gao
author_facet	Xu Li Hongqin Xu Pujun Gao
author_sort	Xu Li
title	Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
title_short	Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
title_full	Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
title_fullStr	Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
title_full_unstemmed	Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
title_sort	increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29ffb46996a347d29eaedc9be58c49f6
work_keys_str_mv	AT xuli increasedredcelldistributionwidthpredictsseverityofdruginducedliverinjuryaretrospectivestudy AT hongqinxu increasedredcelldistributionwidthpredictsseverityofdruginducedliverinjuryaretrospectivestudy AT pujungao increasedredcelldistributionwidthpredictsseverityofdruginducedliverinjuryaretrospectivestudy
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Increased red cell distribution width predicts severity of drug-induced liver injury: a retrospective study

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