The influence of axial myopia on optic disc characteristics of glaucoma eyes

Abstract This study characterizes differences in glaucomatous eyes with and without high axial myopia using custom automated analysis of OCT images. 452 eyes of 277 glaucoma patients were stratified into non (n = 145 eyes), mild (n = 214 eyes), and high axial myopia (axial length (AL) > 26 mm, n ...

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Autores principales:	Jasmin Rezapour, Christopher Bowd, Jade Dohleman, Akram Belghith, James A. Proudfoot, Mark Christopher, Leslie Hyman, Jost B. Jonas, Massimo A. Fazio, Robert N. Weinreb, Linda M. Zangwill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/29ffdc95bc5e4fe3b6a87062477c4de6
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spelling	oai:doaj.org-article:29ffdc95bc5e4fe3b6a87062477c4de62021-12-02T17:33:00ZThe influence of axial myopia on optic disc characteristics of glaucoma eyes10.1038/s41598-021-88406-12045-2322https://doaj.org/article/29ffdc95bc5e4fe3b6a87062477c4de62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88406-1https://doaj.org/toc/2045-2322Abstract This study characterizes differences in glaucomatous eyes with and without high axial myopia using custom automated analysis of OCT images. 452 eyes of 277 glaucoma patients were stratified into non (n = 145 eyes), mild (n = 214 eyes), and high axial myopia (axial length (AL) > 26 mm, n = 93 eyes). Optic disc ovality index, tilt and rotation angle of Bruch´s membrane opening (BMO) and peripapillary choroidal thickness (PCT) were calculated using automated and deep learning strategies. High myopic optic discs were more oval and had larger BMO tilt than mild and non-myopic discs (both p < 0.001). Mean PCT was thinnest in high myopic eyes followed by mild and non-myopic eyes (p < 0.001). BMO rotation angle, global retinal nerve fiber layer (RNFL) thickness and BMO-minimum rim width (MRW) were similar among groups. Temporal RNFL was thicker and supranasal BMO-MRW was thinner in high myopic eyes. BMO tilt and PCT showed moderate and temporal RNFL and nasal BMO-MRW showed weak but significant associations with AL in multivariable analyses (all p < 0.05). Large BMO tilt angle and thin PCT are characteristics of highly myopic discs and were not associated with severity of glaucoma. Caution should be exercised when using sectoral BMO-MRW and RNFL thickness for glaucoma management decisions in myopic eyes.Jasmin RezapourChristopher BowdJade DohlemanAkram BelghithJames A. ProudfootMark ChristopherLeslie HymanJost B. JonasMassimo A. FazioRobert N. WeinrebLinda M. ZangwillNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jasmin Rezapour Christopher Bowd Jade Dohleman Akram Belghith James A. Proudfoot Mark Christopher Leslie Hyman Jost B. Jonas Massimo A. Fazio Robert N. Weinreb Linda M. Zangwill The influence of axial myopia on optic disc characteristics of glaucoma eyes
description	Abstract This study characterizes differences in glaucomatous eyes with and without high axial myopia using custom automated analysis of OCT images. 452 eyes of 277 glaucoma patients were stratified into non (n = 145 eyes), mild (n = 214 eyes), and high axial myopia (axial length (AL) > 26 mm, n = 93 eyes). Optic disc ovality index, tilt and rotation angle of Bruch´s membrane opening (BMO) and peripapillary choroidal thickness (PCT) were calculated using automated and deep learning strategies. High myopic optic discs were more oval and had larger BMO tilt than mild and non-myopic discs (both p < 0.001). Mean PCT was thinnest in high myopic eyes followed by mild and non-myopic eyes (p < 0.001). BMO rotation angle, global retinal nerve fiber layer (RNFL) thickness and BMO-minimum rim width (MRW) were similar among groups. Temporal RNFL was thicker and supranasal BMO-MRW was thinner in high myopic eyes. BMO tilt and PCT showed moderate and temporal RNFL and nasal BMO-MRW showed weak but significant associations with AL in multivariable analyses (all p < 0.05). Large BMO tilt angle and thin PCT are characteristics of highly myopic discs and were not associated with severity of glaucoma. Caution should be exercised when using sectoral BMO-MRW and RNFL thickness for glaucoma management decisions in myopic eyes.
format	article
author	Jasmin Rezapour Christopher Bowd Jade Dohleman Akram Belghith James A. Proudfoot Mark Christopher Leslie Hyman Jost B. Jonas Massimo A. Fazio Robert N. Weinreb Linda M. Zangwill
author_facet	Jasmin Rezapour Christopher Bowd Jade Dohleman Akram Belghith James A. Proudfoot Mark Christopher Leslie Hyman Jost B. Jonas Massimo A. Fazio Robert N. Weinreb Linda M. Zangwill
author_sort	Jasmin Rezapour
title	The influence of axial myopia on optic disc characteristics of glaucoma eyes
title_short	The influence of axial myopia on optic disc characteristics of glaucoma eyes
title_full	The influence of axial myopia on optic disc characteristics of glaucoma eyes
title_fullStr	The influence of axial myopia on optic disc characteristics of glaucoma eyes
title_full_unstemmed	The influence of axial myopia on optic disc characteristics of glaucoma eyes
title_sort	influence of axial myopia on optic disc characteristics of glaucoma eyes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/29ffdc95bc5e4fe3b6a87062477c4de6
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The influence of axial myopia on optic disc characteristics of glaucoma eyes

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