A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women

Objective: To analyze the duration of gonadotropin hyperstimulation's impacts on oocyte quality and clinical outcomes in aged in vitro fertilization (IVF) patients. Materials and methods: This retrospective study was carried out using IVF records of the Chang Gung Memorial Hospital IVF center f...

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Autores principales:	Le Tien Hsu, Tzu Hsuan Chin, Shang Yu Huang, Lan Yan Yang, Yu Bin Pan, Chia Lin Chang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Aged Controlled ovarian hyperstimulation Gonadotropin Infertility IVF Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/2a01bbb284044c2884ef6d1eb6e33765
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spelling	oai:doaj.org-article:2a01bbb284044c2884ef6d1eb6e337652021-11-18T04:44:37ZA short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women1028-455910.1016/j.tjog.2021.09.002https://doaj.org/article/2a01bbb284044c2884ef6d1eb6e337652021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002424https://doaj.org/toc/1028-4559Objective: To analyze the duration of gonadotropin hyperstimulation's impacts on oocyte quality and clinical outcomes in aged in vitro fertilization (IVF) patients. Materials and methods: This retrospective study was carried out using IVF records of the Chang Gung Memorial Hospital IVF center from January 2017 to December 2019. A total of 308 IVF cycles with patients aged 40–44 years were included. Clinical characteristics of patients who received a short controlled ovarian hyperstimulation (COH) (i.e., 6–7 days; s-COH group) or a long COH treatment (i.e., 9–10 days; l-COH group) were compared. In addition, analysis was conducted using data within two age subgroups: 40–42 years and 42–44 years subgroups. Results: The s-COH group received significantly lower total doses of gonadotropin and had smaller leading follicles at the time of ovulation trigger when compared to the l-COH group. The s-COH group also produced a significantly lower number of oocytes, mature metaphase II (MII) oocytes, and 2 PN zygotes compared to the l-COH group. However, there was no significant difference in the number of transferable and good-quality embryos between the two treatment groups. Likewise, the pregnancy rate and live birth rate were comparable in the s-COH and l-COH groups. Similar results were obtained when the analysis was limited to select age subgroups (i.e., 40–42 and 42–44 years subgroups). Conclusion: While a long COH generates more oocytes per cycle, a 6–7 days COH treatment, which is at the lower end of the recommended window of stimulation, could achieve a pregnancy outcome comparable to that applied 9–10 days of COH in aged patients.Le Tien HsuTzu Hsuan ChinShang Yu HuangLan Yan YangYu Bin PanChia Lin ChangElsevierarticleAgedControlled ovarian hyperstimulationGonadotropinInfertilityIVFGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1047-1053 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aged Controlled ovarian hyperstimulation Gonadotropin Infertility IVF Gynecology and obstetrics RG1-991
spellingShingle	Aged Controlled ovarian hyperstimulation Gonadotropin Infertility IVF Gynecology and obstetrics RG1-991 Le Tien Hsu Tzu Hsuan Chin Shang Yu Huang Lan Yan Yang Yu Bin Pan Chia Lin Chang A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women
description	Objective: To analyze the duration of gonadotropin hyperstimulation's impacts on oocyte quality and clinical outcomes in aged in vitro fertilization (IVF) patients. Materials and methods: This retrospective study was carried out using IVF records of the Chang Gung Memorial Hospital IVF center from January 2017 to December 2019. A total of 308 IVF cycles with patients aged 40–44 years were included. Clinical characteristics of patients who received a short controlled ovarian hyperstimulation (COH) (i.e., 6–7 days; s-COH group) or a long COH treatment (i.e., 9–10 days; l-COH group) were compared. In addition, analysis was conducted using data within two age subgroups: 40–42 years and 42–44 years subgroups. Results: The s-COH group received significantly lower total doses of gonadotropin and had smaller leading follicles at the time of ovulation trigger when compared to the l-COH group. The s-COH group also produced a significantly lower number of oocytes, mature metaphase II (MII) oocytes, and 2 PN zygotes compared to the l-COH group. However, there was no significant difference in the number of transferable and good-quality embryos between the two treatment groups. Likewise, the pregnancy rate and live birth rate were comparable in the s-COH and l-COH groups. Similar results were obtained when the analysis was limited to select age subgroups (i.e., 40–42 and 42–44 years subgroups). Conclusion: While a long COH generates more oocytes per cycle, a 6–7 days COH treatment, which is at the lower end of the recommended window of stimulation, could achieve a pregnancy outcome comparable to that applied 9–10 days of COH in aged patients.
format	article
author	Le Tien Hsu Tzu Hsuan Chin Shang Yu Huang Lan Yan Yang Yu Bin Pan Chia Lin Chang
author_facet	Le Tien Hsu Tzu Hsuan Chin Shang Yu Huang Lan Yan Yang Yu Bin Pan Chia Lin Chang
author_sort	Le Tien Hsu
title	A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women
title_short	A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women
title_full	A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women
title_fullStr	A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women
title_full_unstemmed	A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women
title_sort	short length of gonadotropin hyperstimulation is sufficient to achieve an optimal ivf outcome in advance-aged women
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2a01bbb284044c2884ef6d1eb6e33765
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A short length of gonadotropin hyperstimulation is sufficient to achieve an optimal IVF outcome in advance-aged women

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