Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review

Background: The elderly people have high morbimortality associated with respiratory disorders, in addition to the presence of other safety risk factors, such as the use of potentially inappropriate medication and the occurrence of drug interactions. Objective: Considering the current pandemic scena...

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Autores principales:	Marcela Forgerini, Geovana Schiavo, Rosa Camila Lucchetta, Patricia Mastroianni
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2020
Materias:	Coronavirus Infections Contraindications Drug Drug-Related Effects and Adverse Reactions Inappropriate Prescribing Older Adults Potentially Inappropriate Medication List Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/2a0375f7077a4423b4f51cef37c409f3
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spelling	oai:doaj.org-article:2a0375f7077a4423b4f51cef37c409f32021-12-02T19:37:15ZDrug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review10.17533/udea.vitae.v27n3a020121-40042145-2660https://doaj.org/article/2a0375f7077a4423b4f51cef37c409f32020-12-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/343796https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: The elderly people have high morbimortality associated with respiratory disorders, in addition to the presence of other safety risk factors, such as the use of potentially inappropriate medication and the occurrence of drug interactions. Objective: Considering the current pandemic scenario, it was intended to identify explicit criteria-based tools that reported drug interactions between potentially inappropriate medication and respiratory system disorders and possibly worse prognosis of COVID-19 infection. Methods: A systematic scoping review was conducted until February 2020. Study characteristics of explicit criteria-based tools, and potentially inappropriate medication, drug interactions, and therapeutic management, were extracted. Results: Nineteen explicit criteria-based tools were included. Nineteen drug interactions and 17 potentially inappropriate medications with concerns for three respiratory disorders (asthma, chronic pulmonary obstructive disease, and respiratory failure) were identified. The most frequent pharmacological classes reported were benzodiazepines and beta-blockers. For clinical management, the tools recommend using cardioselective beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin II type I receptor blockers, and benzodiazepines with a short or intermediate half-life. Conclusion: Considering the increased risk of COVID-19 infection in the elderly, drug interactions and the use of potentially inappropriate medication associated with the occurrence of adverse drug events in the respiratory system may also worsening COVID-19 infection in patients with uncontrolled respiratory disorders. Thus, it is essential to assess drug therapy in use, to identify safety risks, and monitor the elderly in general and those with a worse prognosis concerning COVID-19, promoting patient safety. Marcela ForgeriniGeovana SchiavoRosa Camila LucchettaPatricia MastroianniUniversidad de AntioquiaarticleCoronavirus InfectionsContraindications DrugDrug-Related Effects and Adverse ReactionsInappropriate PrescribingOlder AdultsPotentially Inappropriate Medication ListFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 27, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coronavirus Infections Contraindications Drug Drug-Related Effects and Adverse Reactions Inappropriate Prescribing Older Adults Potentially Inappropriate Medication List Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Coronavirus Infections Contraindications Drug Drug-Related Effects and Adverse Reactions Inappropriate Prescribing Older Adults Potentially Inappropriate Medication List Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Marcela Forgerini Geovana Schiavo Rosa Camila Lucchetta Patricia Mastroianni Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review
description	Background: The elderly people have high morbimortality associated with respiratory disorders, in addition to the presence of other safety risk factors, such as the use of potentially inappropriate medication and the occurrence of drug interactions. Objective: Considering the current pandemic scenario, it was intended to identify explicit criteria-based tools that reported drug interactions between potentially inappropriate medication and respiratory system disorders and possibly worse prognosis of COVID-19 infection. Methods: A systematic scoping review was conducted until February 2020. Study characteristics of explicit criteria-based tools, and potentially inappropriate medication, drug interactions, and therapeutic management, were extracted. Results: Nineteen explicit criteria-based tools were included. Nineteen drug interactions and 17 potentially inappropriate medications with concerns for three respiratory disorders (asthma, chronic pulmonary obstructive disease, and respiratory failure) were identified. The most frequent pharmacological classes reported were benzodiazepines and beta-blockers. For clinical management, the tools recommend using cardioselective beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin II type I receptor blockers, and benzodiazepines with a short or intermediate half-life. Conclusion: Considering the increased risk of COVID-19 infection in the elderly, drug interactions and the use of potentially inappropriate medication associated with the occurrence of adverse drug events in the respiratory system may also worsening COVID-19 infection in patients with uncontrolled respiratory disorders. Thus, it is essential to assess drug therapy in use, to identify safety risks, and monitor the elderly in general and those with a worse prognosis concerning COVID-19, promoting patient safety.
format	article
author	Marcela Forgerini Geovana Schiavo Rosa Camila Lucchetta Patricia Mastroianni
author_facet	Marcela Forgerini Geovana Schiavo Rosa Camila Lucchetta Patricia Mastroianni
author_sort	Marcela Forgerini
title	Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review
title_short	Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review
title_full	Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review
title_fullStr	Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review
title_full_unstemmed	Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review
title_sort	drug interactions for elderly with respiratory disorders and times of covid-19: a systematic scoping review
publisher	Universidad de Antioquia
publishDate	2020
url	https://doaj.org/article/2a0375f7077a4423b4f51cef37c409f3
work_keys_str_mv	AT marcelaforgerini druginteractionsforelderlywithrespiratorydisordersandtimesofcovid19asystematicscopingreview AT geovanaschiavo druginteractionsforelderlywithrespiratorydisordersandtimesofcovid19asystematicscopingreview AT rosacamilalucchetta druginteractionsforelderlywithrespiratorydisordersandtimesofcovid19asystematicscopingreview AT patriciamastroianni druginteractionsforelderlywithrespiratorydisordersandtimesofcovid19asystematicscopingreview
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Drug interactions for elderly with respiratory disorders and times of COVID-19: a systematic scoping review

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