A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy

Prostate cancer (PC) is one of the most common malignancies among men and is the second leading cause of cancer death. PC immunotherapy has taken relatively successful steps in recent years, and these treatments are still being developed and tested. Evidence suggests that immunotherapy using cytokin...

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Autores principales:	Chenyu Mao, Yongfeng Ding, Nong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	prostate cancer cytokine immunotherapy tumor microenvironment anti-tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2a057f2f4e9240d7af897d40afe50b31
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id	oai:doaj.org-article:2a057f2f4e9240d7af897d40afe50b31
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spelling	oai:doaj.org-article:2a057f2f4e9240d7af897d40afe50b312021-11-16T05:20:54ZA Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy2234-943X10.3389/fonc.2021.688489https://doaj.org/article/2a057f2f4e9240d7af897d40afe50b312021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.688489/fullhttps://doaj.org/toc/2234-943XProstate cancer (PC) is one of the most common malignancies among men and is the second leading cause of cancer death. PC immunotherapy has taken relatively successful steps in recent years, and these treatments are still being developed and tested. Evidence suggests that immunotherapy using cytokines as essential mediators in the immune system may help treat cancer. It has been shown that cytokines play an important role in anti-tumor defense. On the other hand, other cytokines can also favor the tumor and suppress anti-tumor responses. Moreover, the dose of cytokine in cancer cytokine-based immunotherapy, as well as the side effects of high doses, can also affect the outcomes of treatment. Cytokines can also be determinative in the outcome of other immunotherapy methods used in PC. In this review, the role of cytokines in the pathogenesis of cancer and their impacts on the main types of immunotherapies in the treatment of PC are discussed.Chenyu MaoYongfeng DingNong XuFrontiers Media S.A.articleprostate cancercytokineimmunotherapytumor microenvironmentanti-tumorNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer cytokine immunotherapy tumor microenvironment anti-tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prostate cancer cytokine immunotherapy tumor microenvironment anti-tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chenyu Mao Yongfeng Ding Nong Xu A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy
description	Prostate cancer (PC) is one of the most common malignancies among men and is the second leading cause of cancer death. PC immunotherapy has taken relatively successful steps in recent years, and these treatments are still being developed and tested. Evidence suggests that immunotherapy using cytokines as essential mediators in the immune system may help treat cancer. It has been shown that cytokines play an important role in anti-tumor defense. On the other hand, other cytokines can also favor the tumor and suppress anti-tumor responses. Moreover, the dose of cytokine in cancer cytokine-based immunotherapy, as well as the side effects of high doses, can also affect the outcomes of treatment. Cytokines can also be determinative in the outcome of other immunotherapy methods used in PC. In this review, the role of cytokines in the pathogenesis of cancer and their impacts on the main types of immunotherapies in the treatment of PC are discussed.
format	article
author	Chenyu Mao Yongfeng Ding Nong Xu
author_facet	Chenyu Mao Yongfeng Ding Nong Xu
author_sort	Chenyu Mao
title	A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy
title_short	A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy
title_full	A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy
title_fullStr	A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy
title_full_unstemmed	A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy
title_sort	double-edged sword role of cytokines in prostate cancer immunotherapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2a057f2f4e9240d7af897d40afe50b31
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A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy

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