Challenging the Conventional Interpretation of HCMV Seronegativity

The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva, so infection events are likely to be common. Indeed, it is hard to imagine a life without exposure to HCMV. From...

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Autores principales:	Shelley Waters, Silvia Lee, Ashley Irish, Patricia Price
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human cytomegalovirus seronegative NK cells viral IL-10 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2a09ce2ba57e49b99acfbd236a57f181
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spelling	oai:doaj.org-article:2a09ce2ba57e49b99acfbd236a57f1812021-11-25T18:25:34ZChallenging the Conventional Interpretation of HCMV Seronegativity10.3390/microorganisms91123822076-2607https://doaj.org/article/2a09ce2ba57e49b99acfbd236a57f1812021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2382https://doaj.org/toc/2076-2607The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva, so infection events are likely to be common. Indeed, it is hard to imagine a life without exposure to HCMV. From 45 seronegative individuals (13 renal transplant recipients, 32 healthy adults), we present seven cases who had detectable HCMV DNA in their blood and/or saliva, or a CMV-encoded homologue of IL-10 (vIL-10) in their plasma. One case displayed NK cells characteristic of CMV infection before her HCMV DNA became undetectable. In other cases, the infection may persist with seroconversion blocked by vIL-10. Future research should seek mechanisms that can prevent an individual from seroconverting despite a persistent HCMV infection, as HCMV vaccines may not work well in such people.Shelley WatersSilvia LeeAshley IrishPatricia PriceMDPI AGarticlehuman cytomegalovirusseronegativeNK cellsviral IL-10Biology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2382, p 2382 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human cytomegalovirus seronegative NK cells viral IL-10 Biology (General) QH301-705.5
spellingShingle	human cytomegalovirus seronegative NK cells viral IL-10 Biology (General) QH301-705.5 Shelley Waters Silvia Lee Ashley Irish Patricia Price Challenging the Conventional Interpretation of HCMV Seronegativity
description	The majority of adults in the world (around 83%) carry antibodies reactive with HCMV and are thought to retain inactive or latent infections lifelong. The virus is transmitted via saliva, so infection events are likely to be common. Indeed, it is hard to imagine a life without exposure to HCMV. From 45 seronegative individuals (13 renal transplant recipients, 32 healthy adults), we present seven cases who had detectable HCMV DNA in their blood and/or saliva, or a CMV-encoded homologue of IL-10 (vIL-10) in their plasma. One case displayed NK cells characteristic of CMV infection before her HCMV DNA became undetectable. In other cases, the infection may persist with seroconversion blocked by vIL-10. Future research should seek mechanisms that can prevent an individual from seroconverting despite a persistent HCMV infection, as HCMV vaccines may not work well in such people.
format	article
author	Shelley Waters Silvia Lee Ashley Irish Patricia Price
author_facet	Shelley Waters Silvia Lee Ashley Irish Patricia Price
author_sort	Shelley Waters
title	Challenging the Conventional Interpretation of HCMV Seronegativity
title_short	Challenging the Conventional Interpretation of HCMV Seronegativity
title_full	Challenging the Conventional Interpretation of HCMV Seronegativity
title_fullStr	Challenging the Conventional Interpretation of HCMV Seronegativity
title_full_unstemmed	Challenging the Conventional Interpretation of HCMV Seronegativity
title_sort	challenging the conventional interpretation of hcmv seronegativity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2a09ce2ba57e49b99acfbd236a57f181
work_keys_str_mv	AT shelleywaters challengingtheconventionalinterpretationofhcmvseronegativity AT silvialee challengingtheconventionalinterpretationofhcmvseronegativity AT ashleyirish challengingtheconventionalinterpretationofhcmvseronegativity AT patriciaprice challengingtheconventionalinterpretationofhcmvseronegativity
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Challenging the Conventional Interpretation of HCMV Seronegativity

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