A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients

Abstract This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on the post-procedural recovery of orthopedic patients, including functional outcomes and complex regional pain syndrome type I (CRPS I). Literature search using the Medline, Cochrane Library, and Embase...

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Autores principales:	Kuo-Chuan Hung, Min-Hsien Chiang, Shao-Chun Wu, Ying-Jen Chang, Chun-Ning Ho, Li-Kai Wang, Jen-Yin Chen, Kee-Hsin Chen, Cheuk-Kwan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a0e0716e48142e7bd4dedf17bc8dd56
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spelling	oai:doaj.org-article:2a0e0716e48142e7bd4dedf17bc8dd562021-12-02T17:14:58ZA meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients10.1038/s41598-021-88864-72045-2322https://doaj.org/article/2a0e0716e48142e7bd4dedf17bc8dd562021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88864-7https://doaj.org/toc/2045-2322Abstract This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on the post-procedural recovery of orthopedic patients, including functional outcomes and complex regional pain syndrome type I (CRPS I). Literature search using the Medline, Cochrane Library, and Embase databases from inception till March 2021 identified seven eligible randomized controlled trials with 1,361 participants. Forest plot revealed no significant difference in the functional outcomes at 6–12 months [standardized mean difference (SMD) = −0.00, 95% CI − 0.19 to 0.18, 467 patients], risk of overall complications (RR = 0.98, 95% CI 0.68 to 1.39, 426 patients), and pain severity at 3–6 months (SMD = − 0.18, 95% CI − 0.49 to 0.12, 486 patients) between patients with and without oral vitamin C supplementation. Pooled analysis showed that vitamin C treatment reduced the risk of CRPS I regardless of dosage (RR = 0.46, 95% CI 0.25 to 0.85, 1143 patients). In conclusion, the current meta-analysis demonstrated that oral vitamin C supplementation may reduce the risk of complex regional pain syndrome type I but did not improve the functional outcomes in orthopedic patients. Nevertheless, because of the small number of trials included in the present study, further large-scale clinical studies are warranted to support our findings.Kuo-Chuan HungMin-Hsien ChiangShao-Chun WuYing-Jen ChangChun-Ning HoLi-Kai WangJen-Yin ChenKee-Hsin ChenCheuk-Kwan SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuo-Chuan Hung Min-Hsien Chiang Shao-Chun Wu Ying-Jen Chang Chun-Ning Ho Li-Kai Wang Jen-Yin Chen Kee-Hsin Chen Cheuk-Kwan Sun A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
description	Abstract This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on the post-procedural recovery of orthopedic patients, including functional outcomes and complex regional pain syndrome type I (CRPS I). Literature search using the Medline, Cochrane Library, and Embase databases from inception till March 2021 identified seven eligible randomized controlled trials with 1,361 participants. Forest plot revealed no significant difference in the functional outcomes at 6–12 months [standardized mean difference (SMD) = −0.00, 95% CI − 0.19 to 0.18, 467 patients], risk of overall complications (RR = 0.98, 95% CI 0.68 to 1.39, 426 patients), and pain severity at 3–6 months (SMD = − 0.18, 95% CI − 0.49 to 0.12, 486 patients) between patients with and without oral vitamin C supplementation. Pooled analysis showed that vitamin C treatment reduced the risk of CRPS I regardless of dosage (RR = 0.46, 95% CI 0.25 to 0.85, 1143 patients). In conclusion, the current meta-analysis demonstrated that oral vitamin C supplementation may reduce the risk of complex regional pain syndrome type I but did not improve the functional outcomes in orthopedic patients. Nevertheless, because of the small number of trials included in the present study, further large-scale clinical studies are warranted to support our findings.
format	article
author	Kuo-Chuan Hung Min-Hsien Chiang Shao-Chun Wu Ying-Jen Chang Chun-Ning Ho Li-Kai Wang Jen-Yin Chen Kee-Hsin Chen Cheuk-Kwan Sun
author_facet	Kuo-Chuan Hung Min-Hsien Chiang Shao-Chun Wu Ying-Jen Chang Chun-Ning Ho Li-Kai Wang Jen-Yin Chen Kee-Hsin Chen Cheuk-Kwan Sun
author_sort	Kuo-Chuan Hung
title	A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
title_short	A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
title_full	A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
title_fullStr	A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
title_full_unstemmed	A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients
title_sort	meta-analysis of randomized clinical trials on the impact of oral vitamin c supplementation on first-year outcomes in orthopedic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a0e0716e48142e7bd4dedf17bc8dd56
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A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients

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