The implications of subretinal fluid in pachychoroid neovasculopathy

Abstract This study aimed to identify the clinical characteristics and longitudinal changes in exudative pachychoroid neovasculopathy (PNV) and non-exudative PNV. This retrospective cohort study involved 81 eyes of PNV diagnosed by multimodal imaging including optical coherence tomography angiograph...

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Autores principales:	Geun Woo Lee, Hyeon Cheol Roh, Se Woong Kang, A. Young Kim, Hoon Noh, Kyung Jun Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a180b4bda644724885032584e741069
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spelling	oai:doaj.org-article:2a180b4bda644724885032584e7410692021-12-02T14:03:58ZThe implications of subretinal fluid in pachychoroid neovasculopathy10.1038/s41598-021-83650-x2045-2322https://doaj.org/article/2a180b4bda644724885032584e7410692021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83650-xhttps://doaj.org/toc/2045-2322Abstract This study aimed to identify the clinical characteristics and longitudinal changes in exudative pachychoroid neovasculopathy (PNV) and non-exudative PNV. This retrospective cohort study involved 81 eyes of PNV diagnosed by multimodal imaging including optical coherence tomography angiography. At baseline, they were divided into exudative PNV group and non-exudative PNV group depending on the presence of subretinal fluid. The clinical features of both groups and the longitudinal changes were investigated and compared. There were 55 eyes with non-exudative PNV and 26 eyes with exudative PNV. Individuals with non-exudative PNV were older, more frequently asymptomatic and had a higher prevalence of polypoidal choroidal vasculopathy in the opposite eye (all P’s < 0.05). Whereas individuals with exudative PNV showed thicker choroid and more frequent history of central serous chorioretinopathy (all P’s < 0.001). During about 12 months of longitudinal observation, the transformation into polypoidal choroidal vasculopathy was noted in 4 eyes of non-exudative PNV group, whereas in none of the exudative PNV group. Exudative PNV and non-exudative PNV seem to be separate entities with different epidemiological parameters. Non-exudative PNV, which is frequently found without symptoms at an older age, is suspected to be the significant precursor lesion of polypoidal choroidal vasculopathy. In contrast, exudative PNV may share the same pathophysiology as central serous chorioretinopathy.Geun Woo LeeHyeon Cheol RohSe Woong KangA. Young KimHoon NohKyung Jun ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geun Woo Lee Hyeon Cheol Roh Se Woong Kang A. Young Kim Hoon Noh Kyung Jun Choi The implications of subretinal fluid in pachychoroid neovasculopathy
description	Abstract This study aimed to identify the clinical characteristics and longitudinal changes in exudative pachychoroid neovasculopathy (PNV) and non-exudative PNV. This retrospective cohort study involved 81 eyes of PNV diagnosed by multimodal imaging including optical coherence tomography angiography. At baseline, they were divided into exudative PNV group and non-exudative PNV group depending on the presence of subretinal fluid. The clinical features of both groups and the longitudinal changes were investigated and compared. There were 55 eyes with non-exudative PNV and 26 eyes with exudative PNV. Individuals with non-exudative PNV were older, more frequently asymptomatic and had a higher prevalence of polypoidal choroidal vasculopathy in the opposite eye (all P’s < 0.05). Whereas individuals with exudative PNV showed thicker choroid and more frequent history of central serous chorioretinopathy (all P’s < 0.001). During about 12 months of longitudinal observation, the transformation into polypoidal choroidal vasculopathy was noted in 4 eyes of non-exudative PNV group, whereas in none of the exudative PNV group. Exudative PNV and non-exudative PNV seem to be separate entities with different epidemiological parameters. Non-exudative PNV, which is frequently found without symptoms at an older age, is suspected to be the significant precursor lesion of polypoidal choroidal vasculopathy. In contrast, exudative PNV may share the same pathophysiology as central serous chorioretinopathy.
format	article
author	Geun Woo Lee Hyeon Cheol Roh Se Woong Kang A. Young Kim Hoon Noh Kyung Jun Choi
author_facet	Geun Woo Lee Hyeon Cheol Roh Se Woong Kang A. Young Kim Hoon Noh Kyung Jun Choi
author_sort	Geun Woo Lee
title	The implications of subretinal fluid in pachychoroid neovasculopathy
title_short	The implications of subretinal fluid in pachychoroid neovasculopathy
title_full	The implications of subretinal fluid in pachychoroid neovasculopathy
title_fullStr	The implications of subretinal fluid in pachychoroid neovasculopathy
title_full_unstemmed	The implications of subretinal fluid in pachychoroid neovasculopathy
title_sort	implications of subretinal fluid in pachychoroid neovasculopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a180b4bda644724885032584e741069
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The implications of subretinal fluid in pachychoroid neovasculopathy

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