Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

To modulate gene expression, the glucocorticoid receptor binds to response elements (RE) that vary in sequence. Here, the authors show that RE sequences can modulate glucocorticoid receptor structure and activity, which might provide regulatory specificity towards individual target genes.

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Autores principales:	Stefanie Schöne, Marcel Jurk, Mahdi Bagherpoor Helabad, Iris Dror, Isabelle Lebars, Bruno Kieffer, Petra Imhof, Remo Rohs, Martin Vingron, Morgane Thomas-Chollier, Sebastiaan H. Meijsing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a1ad04ab2d040d4bcff1e24f2469042
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spelling	oai:doaj.org-article:2a1ad04ab2d040d4bcff1e24f24690422021-12-02T15:34:09ZSequences flanking the core-binding site modulate glucocorticoid receptor structure and activity10.1038/ncomms126212041-1723https://doaj.org/article/2a1ad04ab2d040d4bcff1e24f24690422016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12621https://doaj.org/toc/2041-1723To modulate gene expression, the glucocorticoid receptor binds to response elements (RE) that vary in sequence. Here, the authors show that RE sequences can modulate glucocorticoid receptor structure and activity, which might provide regulatory specificity towards individual target genes.Stefanie SchöneMarcel JurkMahdi Bagherpoor HelabadIris DrorIsabelle LebarsBruno KiefferPetra ImhofRemo RohsMartin VingronMorgane Thomas-ChollierSebastiaan H. MeijsingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefanie Schöne Marcel Jurk Mahdi Bagherpoor Helabad Iris Dror Isabelle Lebars Bruno Kieffer Petra Imhof Remo Rohs Martin Vingron Morgane Thomas-Chollier Sebastiaan H. Meijsing Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
description	To modulate gene expression, the glucocorticoid receptor binds to response elements (RE) that vary in sequence. Here, the authors show that RE sequences can modulate glucocorticoid receptor structure and activity, which might provide regulatory specificity towards individual target genes.
format	article
author	Stefanie Schöne Marcel Jurk Mahdi Bagherpoor Helabad Iris Dror Isabelle Lebars Bruno Kieffer Petra Imhof Remo Rohs Martin Vingron Morgane Thomas-Chollier Sebastiaan H. Meijsing
author_facet	Stefanie Schöne Marcel Jurk Mahdi Bagherpoor Helabad Iris Dror Isabelle Lebars Bruno Kieffer Petra Imhof Remo Rohs Martin Vingron Morgane Thomas-Chollier Sebastiaan H. Meijsing
author_sort	Stefanie Schöne
title	Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
title_short	Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
title_full	Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
title_fullStr	Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
title_full_unstemmed	Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
title_sort	sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2a1ad04ab2d040d4bcff1e24f2469042
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Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

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