Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder

Abstract Emotion dysregulation is common in attention-deficit/hyperactivity disorder (ADHD). It is highly prevalent in young adult ADHD and related to reduced well-being and social impairments. Neuroimaging studies reported neural activity changes in ADHD in brain regions associated with emotion pro...

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Autores principales:	Tammo Viering, Pieter J. Hoekstra, Alexandra Philipsen, Jilly Naaijen, Andrea Dietrich, Catharina A. Hartman, Jan K. Buitelaar, Andrea Hildebrandt, Carsten Gießing, Christiane M. Thiel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a258c5ff3dd4a7daa799884023e7b90
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spelling	oai:doaj.org-article:2a258c5ff3dd4a7daa799884023e7b902021-12-02T17:03:49ZFunctional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder10.1038/s41598-021-94426-82045-2322https://doaj.org/article/2a258c5ff3dd4a7daa799884023e7b902021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94426-8https://doaj.org/toc/2045-2322Abstract Emotion dysregulation is common in attention-deficit/hyperactivity disorder (ADHD). It is highly prevalent in young adult ADHD and related to reduced well-being and social impairments. Neuroimaging studies reported neural activity changes in ADHD in brain regions associated with emotion processing and regulation. It is however unknown whether deficits in emotion regulation relate to changes in functional brain network topology in these regions. We used a combination of graph analysis and structural equation modelling (SEM) to analyze resting-state functional connectivity in 147 well-characterized young adults with ADHD and age-matched healthy controls from the NeuroIMAGE database. Emotion dysregulation was gauged with four scales obtained from questionnaires and operationalized through a latent variable derived from SEM. Graph analysis was applied to resting-state data and network topology measures were entered into SEM models to identify brain regions whose local network integration and connectedness differed between subjects and was associated with emotion dysregulation. The latent variable of emotion dysregulation was characterized by scales gauging emotional distress, emotional symptoms, conduct symptoms, and emotional lability. In individuals with ADHD characterized by prominent hyperactivity-impulsivity, the latent emotion dysregulation variable was related to an increased clustering and local efficiency of the right insula. Thus, in the presence of hyperactivity-impulsivity, clustered network formation of the right insula may underpin emotion dysregulation in young adult ADHD.Tammo VieringPieter J. HoekstraAlexandra PhilipsenJilly NaaijenAndrea DietrichCatharina A. HartmanJan K. BuitelaarAndrea HildebrandtCarsten GießingChristiane M. ThielNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tammo Viering Pieter J. Hoekstra Alexandra Philipsen Jilly Naaijen Andrea Dietrich Catharina A. Hartman Jan K. Buitelaar Andrea Hildebrandt Carsten Gießing Christiane M. Thiel Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
description	Abstract Emotion dysregulation is common in attention-deficit/hyperactivity disorder (ADHD). It is highly prevalent in young adult ADHD and related to reduced well-being and social impairments. Neuroimaging studies reported neural activity changes in ADHD in brain regions associated with emotion processing and regulation. It is however unknown whether deficits in emotion regulation relate to changes in functional brain network topology in these regions. We used a combination of graph analysis and structural equation modelling (SEM) to analyze resting-state functional connectivity in 147 well-characterized young adults with ADHD and age-matched healthy controls from the NeuroIMAGE database. Emotion dysregulation was gauged with four scales obtained from questionnaires and operationalized through a latent variable derived from SEM. Graph analysis was applied to resting-state data and network topology measures were entered into SEM models to identify brain regions whose local network integration and connectedness differed between subjects and was associated with emotion dysregulation. The latent variable of emotion dysregulation was characterized by scales gauging emotional distress, emotional symptoms, conduct symptoms, and emotional lability. In individuals with ADHD characterized by prominent hyperactivity-impulsivity, the latent emotion dysregulation variable was related to an increased clustering and local efficiency of the right insula. Thus, in the presence of hyperactivity-impulsivity, clustered network formation of the right insula may underpin emotion dysregulation in young adult ADHD.
format	article
author	Tammo Viering Pieter J. Hoekstra Alexandra Philipsen Jilly Naaijen Andrea Dietrich Catharina A. Hartman Jan K. Buitelaar Andrea Hildebrandt Carsten Gießing Christiane M. Thiel
author_facet	Tammo Viering Pieter J. Hoekstra Alexandra Philipsen Jilly Naaijen Andrea Dietrich Catharina A. Hartman Jan K. Buitelaar Andrea Hildebrandt Carsten Gießing Christiane M. Thiel
author_sort	Tammo Viering
title	Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
title_short	Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
title_full	Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
title_fullStr	Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
title_full_unstemmed	Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
title_sort	functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a258c5ff3dd4a7daa799884023e7b90
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Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder

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