Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions

The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked to the release of anti-inflammatory cytokines...

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Autores principales:	Minjoo Han, Gyoungah Ryu, Seong-Ah Shin, Jangeun An, Huiji Kim, Daeho Park, Dae-Hee Lee, Chang Sup Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	apoptosis apoptotic cell clearance differentiation development inflammation phagocyte Science Q
Acceso en línea:	https://doaj.org/article/2a25e3e33ba34f02a2a00f6e7a9c260d
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spelling	oai:doaj.org-article:2a25e3e33ba34f02a2a00f6e7a9c260d2021-11-25T18:10:36ZPhysiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions10.3390/life111111412075-1729https://doaj.org/article/2a25e3e33ba34f02a2a00f6e7a9c260d2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1141https://doaj.org/toc/2075-1729The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked to the release of anti-inflammatory cytokines to eliminate inflammatory responses. Defective clearance of apoptotic cells can cause severe inflammation and autoimmune responses due to secondary necrosis of apoptotic cells. Recently accumulated evidence indicates that apoptotic cells and their clearance have important physiological roles in addition to immune-related functions. Herein, we review the current understanding of the mechanisms and fundamental roles of apoptotic cell clearance and the beneficial roles of apoptotic cells in physiological processes such as differentiation and development.Minjoo HanGyoungah RyuSeong-Ah ShinJangeun AnHuiji KimDaeho ParkDae-Hee LeeChang Sup LeeMDPI AGarticleapoptosisapoptotic cell clearancedifferentiationdevelopmentinflammationphagocyteScienceQENLife, Vol 11, Iss 1141, p 1141 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis apoptotic cell clearance differentiation development inflammation phagocyte Science Q
spellingShingle	apoptosis apoptotic cell clearance differentiation development inflammation phagocyte Science Q Minjoo Han Gyoungah Ryu Seong-Ah Shin Jangeun An Huiji Kim Daeho Park Dae-Hee Lee Chang Sup Lee Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
description	The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked to the release of anti-inflammatory cytokines to eliminate inflammatory responses. Defective clearance of apoptotic cells can cause severe inflammation and autoimmune responses due to secondary necrosis of apoptotic cells. Recently accumulated evidence indicates that apoptotic cells and their clearance have important physiological roles in addition to immune-related functions. Herein, we review the current understanding of the mechanisms and fundamental roles of apoptotic cell clearance and the beneficial roles of apoptotic cells in physiological processes such as differentiation and development.
format	article
author	Minjoo Han Gyoungah Ryu Seong-Ah Shin Jangeun An Huiji Kim Daeho Park Dae-Hee Lee Chang Sup Lee
author_facet	Minjoo Han Gyoungah Ryu Seong-Ah Shin Jangeun An Huiji Kim Daeho Park Dae-Hee Lee Chang Sup Lee
author_sort	Minjoo Han
title	Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
title_short	Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
title_full	Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
title_fullStr	Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
title_full_unstemmed	Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
title_sort	physiological roles of apoptotic cell clearance: beyond immune functions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2a25e3e33ba34f02a2a00f6e7a9c260d
work_keys_str_mv	AT minjoohan physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT gyoungahryu physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT seongahshin physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT jangeunan physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT huijikim physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT daehopark physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT daeheelee physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions AT changsuplee physiologicalrolesofapoptoticcellclearancebeyondimmunefunctions
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Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions

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