Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis
The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signal...
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Nature Portfolio
2018
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oai:doaj.org-article:2a266070415e43ab8b818dd620dfebf52021-12-02T15:33:34ZMacrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis10.1038/s41467-018-03764-12041-1723https://doaj.org/article/2a266070415e43ab8b818dd620dfebf52018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03764-1https://doaj.org/toc/2041-1723The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signaling.Karim C. El KasmiPadade M. VueAimee L. AndersonMichael W. DevereauxSwati GhoshNatarajan BalasubramaniyanSophie A. FillonCarola DahrenmoellerAyed AllawziCrystal WoodsSarah McKennaClyde J. WrightLinda JohnsonAngelo D’AlessandroJulie A. ReiszEva Nozik-GrayckFrederick J. SuchyRonald J. SokolNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Karim C. El Kasmi Padade M. Vue Aimee L. Anderson Michael W. Devereaux Swati Ghosh Natarajan Balasubramaniyan Sophie A. Fillon Carola Dahrenmoeller Ayed Allawzi Crystal Woods Sarah McKenna Clyde J. Wright Linda Johnson Angelo D’Alessandro Julie A. Reisz Eva Nozik-Grayck Frederick J. Suchy Ronald J. Sokol Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| description |
The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signaling. |
| format |
article |
| author |
Karim C. El Kasmi Padade M. Vue Aimee L. Anderson Michael W. Devereaux Swati Ghosh Natarajan Balasubramaniyan Sophie A. Fillon Carola Dahrenmoeller Ayed Allawzi Crystal Woods Sarah McKenna Clyde J. Wright Linda Johnson Angelo D’Alessandro Julie A. Reisz Eva Nozik-Grayck Frederick J. Suchy Ronald J. Sokol |
| author_facet |
Karim C. El Kasmi Padade M. Vue Aimee L. Anderson Michael W. Devereaux Swati Ghosh Natarajan Balasubramaniyan Sophie A. Fillon Carola Dahrenmoeller Ayed Allawzi Crystal Woods Sarah McKenna Clyde J. Wright Linda Johnson Angelo D’Alessandro Julie A. Reisz Eva Nozik-Grayck Frederick J. Suchy Ronald J. Sokol |
| author_sort |
Karim C. El Kasmi |
| title |
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_short |
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_full |
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_fullStr |
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_full_unstemmed |
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis |
| title_sort |
macrophage-derived il-1β/nf-κb signaling mediates parenteral nutrition-associated cholestasis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/2a266070415e43ab8b818dd620dfebf5 |
| work_keys_str_mv |
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