Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic...

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Autores principales: Jasper Iske, Midas Seyda, Timm Heinbokel, Ryoichi Maenosono, Koichiro Minami, Yeqi Nian, Markus Quante, Christine S. Falk, Haruhito Azuma, Friederike Martin, João F. Passos, Claus U. Niemann, Tamara Tchkonia, James L. Kirkland, Abdallah Elkhal, Stefan G. Tullius
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60
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Sumario:Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.

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