Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic...

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Autores principales:	Jasper Iske, Midas Seyda, Timm Heinbokel, Ryoichi Maenosono, Koichiro Minami, Yeqi Nian, Markus Quante, Christine S. Falk, Haruhito Azuma, Friederike Martin, João F. Passos, Claus U. Niemann, Tamara Tchkonia, James L. Kirkland, Abdallah Elkhal, Stefan G. Tullius
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60
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spelling	oai:doaj.org-article:2a2a4da6a7984ebfa0d0c386e1408c602021-12-02T19:02:33ZSenolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation10.1038/s41467-020-18039-x2041-1723https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c602020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18039-xhttps://doaj.org/toc/2041-1723Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.Jasper IskeMidas SeydaTimm HeinbokelRyoichi MaenosonoKoichiro MinamiYeqi NianMarkus QuanteChristine S. FalkHaruhito AzumaFriederike MartinJoão F. PassosClaus U. NiemannTamara TchkoniaJames L. KirklandAbdallah ElkhalStefan G. TulliusNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jasper Iske Midas Seyda Timm Heinbokel Ryoichi Maenosono Koichiro Minami Yeqi Nian Markus Quante Christine S. Falk Haruhito Azuma Friederike Martin João F. Passos Claus U. Niemann Tamara Tchkonia James L. Kirkland Abdallah Elkhal Stefan G. Tullius Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
description	Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.
format	article
author	Jasper Iske Midas Seyda Timm Heinbokel Ryoichi Maenosono Koichiro Minami Yeqi Nian Markus Quante Christine S. Falk Haruhito Azuma Friederike Martin João F. Passos Claus U. Niemann Tamara Tchkonia James L. Kirkland Abdallah Elkhal Stefan G. Tullius
author_facet	Jasper Iske Midas Seyda Timm Heinbokel Ryoichi Maenosono Koichiro Minami Yeqi Nian Markus Quante Christine S. Falk Haruhito Azuma Friederike Martin João F. Passos Claus U. Niemann Tamara Tchkonia James L. Kirkland Abdallah Elkhal Stefan G. Tullius
author_sort	Jasper Iske
title	Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
title_short	Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
title_full	Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
title_fullStr	Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
title_full_unstemmed	Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
title_sort	senolytics prevent mt-dna-induced inflammation and promote the survival of aged organs following transplantation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60
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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

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