Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic...

Full description

Saved in:
Bibliographic Details
Main Authors: Jasper Iske, Midas Seyda, Timm Heinbokel, Ryoichi Maenosono, Koichiro Minami, Yeqi Nian, Markus Quante, Christine S. Falk, Haruhito Azuma, Friederike Martin, João F. Passos, Claus U. Niemann, Tamara Tchkonia, James L. Kirkland, Abdallah Elkhal, Stefan G. Tullius
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/2a2a4da6a7984ebfa0d0c386e1408c60

Similar Items