Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that these domains fuel CpG island hypermethylation.
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Nature Portfolio
2019
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oai:doaj.org-article:2a2b3c50b9604a109e1e00c8b53b792f2021-12-02T15:35:54ZPartially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation10.1038/s41467-019-09828-02041-1723https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09828-0https://doaj.org/toc/2041-1723In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that these domains fuel CpG island hypermethylation.Arie B. BrinkmanSerena Nik-ZainalFemke SimmerF. Germán Rodríguez-GonzálezMarcel SmidLudmil B. AlexandrovAdam ButlerSancha MartinHelen DaviesDominik GlodzikXueqing ZouManasa RamakrishnaJohan StaafMarkus RingnérAnieta SieuwertsAnthony FerrariSandro MorganellaThomas FleischerVessela KristensenMarta GutMarc J. van de VijverAnne-Lise Børresen-DaleAndrea L. RichardsonGilles ThomasIvo G. GutJohn W. M. MartensJohn A. FoekensMichael R. StrattonHendrik G. StunnenbergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Arie B. Brinkman Serena Nik-Zainal Femke Simmer F. Germán Rodríguez-González Marcel Smid Ludmil B. Alexandrov Adam Butler Sancha Martin Helen Davies Dominik Glodzik Xueqing Zou Manasa Ramakrishna Johan Staaf Markus Ringnér Anieta Sieuwerts Anthony Ferrari Sandro Morganella Thomas Fleischer Vessela Kristensen Marta Gut Marc J. van de Vijver Anne-Lise Børresen-Dale Andrea L. Richardson Gilles Thomas Ivo G. Gut John W. M. Martens John A. Foekens Michael R. Stratton Hendrik G. Stunnenberg Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation |
| description |
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that these domains fuel CpG island hypermethylation. |
| format |
article |
| author |
Arie B. Brinkman Serena Nik-Zainal Femke Simmer F. Germán Rodríguez-González Marcel Smid Ludmil B. Alexandrov Adam Butler Sancha Martin Helen Davies Dominik Glodzik Xueqing Zou Manasa Ramakrishna Johan Staaf Markus Ringnér Anieta Sieuwerts Anthony Ferrari Sandro Morganella Thomas Fleischer Vessela Kristensen Marta Gut Marc J. van de Vijver Anne-Lise Børresen-Dale Andrea L. Richardson Gilles Thomas Ivo G. Gut John W. M. Martens John A. Foekens Michael R. Stratton Hendrik G. Stunnenberg |
| author_facet |
Arie B. Brinkman Serena Nik-Zainal Femke Simmer F. Germán Rodríguez-González Marcel Smid Ludmil B. Alexandrov Adam Butler Sancha Martin Helen Davies Dominik Glodzik Xueqing Zou Manasa Ramakrishna Johan Staaf Markus Ringnér Anieta Sieuwerts Anthony Ferrari Sandro Morganella Thomas Fleischer Vessela Kristensen Marta Gut Marc J. van de Vijver Anne-Lise Børresen-Dale Andrea L. Richardson Gilles Thomas Ivo G. Gut John W. M. Martens John A. Foekens Michael R. Stratton Hendrik G. Stunnenberg |
| author_sort |
Arie B. Brinkman |
| title |
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation |
| title_short |
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation |
| title_full |
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation |
| title_fullStr |
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation |
| title_full_unstemmed |
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation |
| title_sort |
partially methylated domains are hypervariable in breast cancer and fuel widespread cpg island hypermethylation |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f |
| work_keys_str_mv |
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