Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that these domains fuel CpG island hypermethylation.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Documents similaires