Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes

Abstract For recent years, devices that generate non-thermal plasma (NTP) have been introduced into the field of dermatology. Since NTP has demonstrated strong anti-pathogenic activity with safety of use, NTP was first applied to sterilize the skin surface to aid in the healing of various kinds of s...

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Autores principales:	J. H. Choi, Y. S. Song, K. Song, H. J. Lee, J. W. Hong, G. C. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a2e86a634ff42928bb585d8f56e12b9
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spelling	oai:doaj.org-article:2a2e86a634ff42928bb585d8f56e12b92021-12-02T11:53:06ZSkin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes10.1038/s41598-017-06661-72045-2322https://doaj.org/article/2a2e86a634ff42928bb585d8f56e12b92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06661-7https://doaj.org/toc/2045-2322Abstract For recent years, devices that generate non-thermal plasma (NTP) have been introduced into the field of dermatology. Since NTP has demonstrated strong anti-pathogenic activity with safety of use, NTP was first applied to sterilize the skin surface to aid in the healing of various kinds of skin diseases. However, the effect of NTP on skin regeneration has not yet been fully explored. In this study, the effect of NTP on the growth of keratinocytes was tested using the HaCaT human keratinocyte cell line and HRM2 hairless mice. Treatment with NTP allowed confluent keratinocytes to escape from G1 cell cycle arrest and increased the proportion of cells in S and G2 phases. In particular, NTP treatment immediately dispersed E-cadherin-mediated cell-to-cell interactions, resulting in the translocation of β-catenin to the nucleus and leading to the enhanced transcription of target genes including c-MYC and cyclin D1. Moreover, repeated treatment of the mice with NTP also stimulated epidermal expansion by activating β-catenin in the epidermal cells. The symptoms of cellular DNA damage were not detected after NTP treatment. Taken together, these results demonstrate that NTP may be employed as a new type of skin regenerating device.J. H. ChoiY. S. SongK. SongH. J. LeeJ. W. HongG. C. KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. H. Choi Y. S. Song K. Song H. J. Lee J. W. Hong G. C. Kim Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
description	Abstract For recent years, devices that generate non-thermal plasma (NTP) have been introduced into the field of dermatology. Since NTP has demonstrated strong anti-pathogenic activity with safety of use, NTP was first applied to sterilize the skin surface to aid in the healing of various kinds of skin diseases. However, the effect of NTP on skin regeneration has not yet been fully explored. In this study, the effect of NTP on the growth of keratinocytes was tested using the HaCaT human keratinocyte cell line and HRM2 hairless mice. Treatment with NTP allowed confluent keratinocytes to escape from G1 cell cycle arrest and increased the proportion of cells in S and G2 phases. In particular, NTP treatment immediately dispersed E-cadherin-mediated cell-to-cell interactions, resulting in the translocation of β-catenin to the nucleus and leading to the enhanced transcription of target genes including c-MYC and cyclin D1. Moreover, repeated treatment of the mice with NTP also stimulated epidermal expansion by activating β-catenin in the epidermal cells. The symptoms of cellular DNA damage were not detected after NTP treatment. Taken together, these results demonstrate that NTP may be employed as a new type of skin regenerating device.
format	article
author	J. H. Choi Y. S. Song K. Song H. J. Lee J. W. Hong G. C. Kim
author_facet	J. H. Choi Y. S. Song K. Song H. J. Lee J. W. Hong G. C. Kim
author_sort	J. H. Choi
title	Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
title_short	Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
title_full	Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
title_fullStr	Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
title_full_unstemmed	Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
title_sort	skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2a2e86a634ff42928bb585d8f56e12b9
work_keys_str_mv	AT jhchoi skinrenewalactivityofnonthermalplasmathroughtheactivationofbcatenininkeratinocytes AT yssong skinrenewalactivityofnonthermalplasmathroughtheactivationofbcatenininkeratinocytes AT ksong skinrenewalactivityofnonthermalplasmathroughtheactivationofbcatenininkeratinocytes AT hjlee skinrenewalactivityofnonthermalplasmathroughtheactivationofbcatenininkeratinocytes AT jwhong skinrenewalactivityofnonthermalplasmathroughtheactivationofbcatenininkeratinocytes AT gckim skinrenewalactivityofnonthermalplasmathroughtheactivationofbcatenininkeratinocytes
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Skin renewal activity of non-thermal plasma through the activation of β-catenin in keratinocytes

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