Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung

Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2.

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Autores principales: Abhishek Tyagi, Sambad Sharma, Kerui Wu, Shih-Ying Wu, Fei Xing, Yin Liu, Dan Zhao, Ravindra Pramod Deshpande, Ralph B. D’Agostino, Kounosuke Watabe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2a319ba611274da7b30af1d518449ce5
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spelling oai:doaj.org-article:2a319ba611274da7b30af1d518449ce52021-12-02T10:49:32ZNicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung10.1038/s41467-020-20733-92041-1723https://doaj.org/article/2a319ba611274da7b30af1d518449ce52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20733-9https://doaj.org/toc/2041-1723Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2.Abhishek TyagiSambad SharmaKerui WuShih-Ying WuFei XingYin LiuDan ZhaoRavindra Pramod DeshpandeRalph B. D’AgostinoKounosuke WatabeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Abhishek Tyagi
Sambad Sharma
Kerui Wu
Shih-Ying Wu
Fei Xing
Yin Liu
Dan Zhao
Ravindra Pramod Deshpande
Ralph B. D’Agostino
Kounosuke Watabe
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
description Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2.
format article
author Abhishek Tyagi
Sambad Sharma
Kerui Wu
Shih-Ying Wu
Fei Xing
Yin Liu
Dan Zhao
Ravindra Pramod Deshpande
Ralph B. D’Agostino
Kounosuke Watabe
author_facet Abhishek Tyagi
Sambad Sharma
Kerui Wu
Shih-Ying Wu
Fei Xing
Yin Liu
Dan Zhao
Ravindra Pramod Deshpande
Ralph B. D’Agostino
Kounosuke Watabe
author_sort Abhishek Tyagi
title Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
title_short Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
title_full Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
title_fullStr Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
title_full_unstemmed Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
title_sort nicotine promotes breast cancer metastasis by stimulating n2 neutrophils and generating pre-metastatic niche in lung
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2a319ba611274da7b30af1d518449ce5
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