Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung
Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2.
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Nature Portfolio
2021
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oai:doaj.org-article:2a319ba611274da7b30af1d518449ce52021-12-02T10:49:32ZNicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung10.1038/s41467-020-20733-92041-1723https://doaj.org/article/2a319ba611274da7b30af1d518449ce52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20733-9https://doaj.org/toc/2041-1723Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2.Abhishek TyagiSambad SharmaKerui WuShih-Ying WuFei XingYin LiuDan ZhaoRavindra Pramod DeshpandeRalph B. D’AgostinoKounosuke WatabeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Abhishek Tyagi Sambad Sharma Kerui Wu Shih-Ying Wu Fei Xing Yin Liu Dan Zhao Ravindra Pramod Deshpande Ralph B. D’Agostino Kounosuke Watabe Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung |
description |
Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2. |
format |
article |
author |
Abhishek Tyagi Sambad Sharma Kerui Wu Shih-Ying Wu Fei Xing Yin Liu Dan Zhao Ravindra Pramod Deshpande Ralph B. D’Agostino Kounosuke Watabe |
author_facet |
Abhishek Tyagi Sambad Sharma Kerui Wu Shih-Ying Wu Fei Xing Yin Liu Dan Zhao Ravindra Pramod Deshpande Ralph B. D’Agostino Kounosuke Watabe |
author_sort |
Abhishek Tyagi |
title |
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung |
title_short |
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung |
title_full |
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung |
title_fullStr |
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung |
title_full_unstemmed |
Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung |
title_sort |
nicotine promotes breast cancer metastasis by stimulating n2 neutrophils and generating pre-metastatic niche in lung |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/2a319ba611274da7b30af1d518449ce5 |
work_keys_str_mv |
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