Thyroid dysfunction in COVID-19
Objective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing...
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Wolters Kluwer Medknow Publications
2021
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oai:doaj.org-article:2a329787220c41778287b0651067a93f2021-11-12T10:10:55ZThyroid dysfunction in COVID-192230-821010.4103/ijem.ijem_195_21https://doaj.org/article/2a329787220c41778287b0651067a93f2021-01-01T00:00:00Zhttp://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=3;spage=198;epage=201;aulast=Dabashttps://doaj.org/toc/2230-8210Objective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing thyroid disease were excluded. The thyroid function tests were performed and correlated with interleukin-6 levels. Results: A total of 164 patients (14 children) with mean(SD) age 53.85 (19.54) years were recruited. The proportion of patients with mild, moderate and severe disease were 22 (13.4%), 78 (47.6%) and 64 (39.0%), respectively, among which 12 (54.5%), 56 (71.8%) and 43 (67.2%) patients had thyroid dysfunction, respectively; P = 0.309. Eighty eight (53.7%) had sick euthyroid (84 had low fT3 only), 14 had overt hypothyroidism and 9 had thyroiditis. Median (IQR) levels of serum fT3 showed significant decline from mild category [4.54 (3.81, 5.27)], to moderate [3.95 (3.67, 4.24)] and severe category [3.56 (3.22, 3.89)]; P = 0.011. Low fT3 had significant risk [odds ratio (95% CI)] of death [2.634 (1.01, 6.87); P = 0.031] and elevated IL-6 [2.575 (1.084, 6.118); P = 0.021]. Conclusion: Sick euthyroid was seen in the majority of patients hospitalized with COVID. Low fT3 was associated with death and increased inflammation, suggesting poor prognosis.Aashima DabasHarpreet SinghBinita GoswamiKunal KumarAbhishek DubeyUrmila JhambSangeeta YadavSandeep GargWolters Kluwer Medknow Publicationsarticlehypothyroidismil-6inflammatory markersick euthyroidthyroiditisDiseases of the endocrine glands. Clinical endocrinologyRC648-665Diseases of the digestive system. GastroenterologyRC799-869ENIndian Journal of Endocrinology and Metabolism, Vol 25, Iss 3, Pp 198-201 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
hypothyroidism il-6 inflammatory marker sick euthyroid thyroiditis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the digestive system. Gastroenterology RC799-869 |
| spellingShingle |
hypothyroidism il-6 inflammatory marker sick euthyroid thyroiditis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the digestive system. Gastroenterology RC799-869 Aashima Dabas Harpreet Singh Binita Goswami Kunal Kumar Abhishek Dubey Urmila Jhamb Sangeeta Yadav Sandeep Garg Thyroid dysfunction in COVID-19 |
| description |
Objective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing thyroid disease were excluded. The thyroid function tests were performed and correlated with interleukin-6 levels. Results: A total of 164 patients (14 children) with mean(SD) age 53.85 (19.54) years were recruited. The proportion of patients with mild, moderate and severe disease were 22 (13.4%), 78 (47.6%) and 64 (39.0%), respectively, among which 12 (54.5%), 56 (71.8%) and 43 (67.2%) patients had thyroid dysfunction, respectively; P = 0.309. Eighty eight (53.7%) had sick euthyroid (84 had low fT3 only), 14 had overt hypothyroidism and 9 had thyroiditis. Median (IQR) levels of serum fT3 showed significant decline from mild category [4.54 (3.81, 5.27)], to moderate [3.95 (3.67, 4.24)] and severe category [3.56 (3.22, 3.89)]; P = 0.011. Low fT3 had significant risk [odds ratio (95% CI)] of death [2.634 (1.01, 6.87); P = 0.031] and elevated IL-6 [2.575 (1.084, 6.118); P = 0.021]. Conclusion: Sick euthyroid was seen in the majority of patients hospitalized with COVID. Low fT3 was associated with death and increased inflammation, suggesting poor prognosis. |
| format |
article |
| author |
Aashima Dabas Harpreet Singh Binita Goswami Kunal Kumar Abhishek Dubey Urmila Jhamb Sangeeta Yadav Sandeep Garg |
| author_facet |
Aashima Dabas Harpreet Singh Binita Goswami Kunal Kumar Abhishek Dubey Urmila Jhamb Sangeeta Yadav Sandeep Garg |
| author_sort |
Aashima Dabas |
| title |
Thyroid dysfunction in COVID-19 |
| title_short |
Thyroid dysfunction in COVID-19 |
| title_full |
Thyroid dysfunction in COVID-19 |
| title_fullStr |
Thyroid dysfunction in COVID-19 |
| title_full_unstemmed |
Thyroid dysfunction in COVID-19 |
| title_sort |
thyroid dysfunction in covid-19 |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/2a329787220c41778287b0651067a93f |
| work_keys_str_mv |
AT aashimadabas thyroiddysfunctionincovid19 AT harpreetsingh thyroiddysfunctionincovid19 AT binitagoswami thyroiddysfunctionincovid19 AT kunalkumar thyroiddysfunctionincovid19 AT abhishekdubey thyroiddysfunctionincovid19 AT urmilajhamb thyroiddysfunctionincovid19 AT sangeetayadav thyroiddysfunctionincovid19 AT sandeepgarg thyroiddysfunctionincovid19 |
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