Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome

Abstract The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative s...

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Autores principales:	Gema Frühbeck, Victoria Catalán, Amaia Rodríguez, Beatriz Ramírez, Sara Becerril, Javier Salvador, Piero Portincasa, Inmaculada Colina, Javier Gómez-Ambrosi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2a36a18cf6754b04b71182003610214d
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spelling	oai:doaj.org-article:2a36a18cf6754b04b71182003610214d2021-12-02T11:52:27ZInvolvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome10.1038/s41598-017-06997-02045-2322https://doaj.org/article/2a36a18cf6754b04b71182003610214d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06997-0https://doaj.org/toc/2045-2322Abstract The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28–82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS. The ratio adiponectin/leptin, a marker of dysfunctional adipose tissue, was dramatically decreased in the MS group. Systemic oxidative stress, as evidenced by levels of thiobarbituric acid reactive substances (TBARS), as well as markers of inflammation such as serum amyloid A (SAA), C-reactive protein (CRP) and osteopontin were significantly increased in subjects with the MS. Total adiponectin concentrations were negatively correlated with levels of TBARS and CRP levels. Furthermore, the ratio adiponectin/leptin was negatively correlated with SAA concentrations as well as with CRP levels. We concluded that a dysfunctional adipose tissue as suggested by a low adiponectin/leptin ratio may contribute to the increased oxidative stress and inflammation, hallmarks of the MS.Gema FrühbeckVictoria CatalánAmaia RodríguezBeatriz RamírezSara BecerrilJavier SalvadorPiero PortincasaInmaculada ColinaJavier Gómez-AmbrosiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gema Frühbeck Victoria Catalán Amaia Rodríguez Beatriz Ramírez Sara Becerril Javier Salvador Piero Portincasa Inmaculada Colina Javier Gómez-Ambrosi Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
description	Abstract The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28–82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS. The ratio adiponectin/leptin, a marker of dysfunctional adipose tissue, was dramatically decreased in the MS group. Systemic oxidative stress, as evidenced by levels of thiobarbituric acid reactive substances (TBARS), as well as markers of inflammation such as serum amyloid A (SAA), C-reactive protein (CRP) and osteopontin were significantly increased in subjects with the MS. Total adiponectin concentrations were negatively correlated with levels of TBARS and CRP levels. Furthermore, the ratio adiponectin/leptin was negatively correlated with SAA concentrations as well as with CRP levels. We concluded that a dysfunctional adipose tissue as suggested by a low adiponectin/leptin ratio may contribute to the increased oxidative stress and inflammation, hallmarks of the MS.
format	article
author	Gema Frühbeck Victoria Catalán Amaia Rodríguez Beatriz Ramírez Sara Becerril Javier Salvador Piero Portincasa Inmaculada Colina Javier Gómez-Ambrosi
author_facet	Gema Frühbeck Victoria Catalán Amaia Rodríguez Beatriz Ramírez Sara Becerril Javier Salvador Piero Portincasa Inmaculada Colina Javier Gómez-Ambrosi
author_sort	Gema Frühbeck
title	Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
title_short	Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
title_full	Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
title_fullStr	Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
title_full_unstemmed	Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
title_sort	involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2a36a18cf6754b04b71182003610214d
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Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome

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