Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation

Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation

B cell affinity maturation occurs in the germinal center (GC). Light-zone (LZ) GC B cells (BGC-cells) interact with follicular dendritic cells (FDCs) and compete for the limited, sequential help from T follicular helper cells needed to escape from apoptosis and complete their differentiation. The hi...

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Detalles Bibliográficos
Autores principales: Kathleen Santamaria, Fabienne Desmots, Simon Leonard, Gersende Caron, Marion Haas, Céline Delaloy, Fabrice Chatonnet, Delphine Rossille, Amandine Pignarre, Céline Monvoisin, Marine Seffals, Claire Lamaison, Michel Cogné, Karin Tarte, Thierry Fest
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
germinal center (GC)
germinal center (GC) B cells
CD23+ B cells
B cell differentiation
plasmablasts/plasma cells
GC Light-Zone B cells
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/2a37c82726ad4a66bf158171a125e426
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