Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells

Haematopoietic stem cell (HSC) self-renewal is not sufficiently understood to recapitulate in vitro. Here, the authors generate gene signature and cell cycle hallmarks of single murine HSCs, and use identified endothelial receptors Esam and JamC as substrates to enhance HSC growth in engineered nich...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aline Roch, Sonja Giger, Mukul Girotra, Vasco Campos, Nicola Vannini, Olaia Naveiras, Samy Gobaa, Matthias P. Lutolf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a3e06912cf94e5189f5b67d9ba35d31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2a3e06912cf94e5189f5b67d9ba35d31
record_format	dspace
spelling	oai:doaj.org-article:2a3e06912cf94e5189f5b67d9ba35d312021-12-02T10:48:10ZSingle-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells10.1038/s41467-017-00291-32041-1723https://doaj.org/article/2a3e06912cf94e5189f5b67d9ba35d312017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00291-3https://doaj.org/toc/2041-1723Haematopoietic stem cell (HSC) self-renewal is not sufficiently understood to recapitulate in vitro. Here, the authors generate gene signature and cell cycle hallmarks of single murine HSCs, and use identified endothelial receptors Esam and JamC as substrates to enhance HSC growth in engineered niches.Aline RochSonja GigerMukul GirotraVasco CamposNicola VanniniOlaia NaveirasSamy GobaaMatthias P. LutolfNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aline Roch Sonja Giger Mukul Girotra Vasco Campos Nicola Vannini Olaia Naveiras Samy Gobaa Matthias P. Lutolf Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
description	Haematopoietic stem cell (HSC) self-renewal is not sufficiently understood to recapitulate in vitro. Here, the authors generate gene signature and cell cycle hallmarks of single murine HSCs, and use identified endothelial receptors Esam and JamC as substrates to enhance HSC growth in engineered niches.
format	article
author	Aline Roch Sonja Giger Mukul Girotra Vasco Campos Nicola Vannini Olaia Naveiras Samy Gobaa Matthias P. Lutolf
author_facet	Aline Roch Sonja Giger Mukul Girotra Vasco Campos Nicola Vannini Olaia Naveiras Samy Gobaa Matthias P. Lutolf
author_sort	Aline Roch
title	Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
title_short	Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
title_full	Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
title_fullStr	Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
title_full_unstemmed	Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
title_sort	single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2a3e06912cf94e5189f5b67d9ba35d31
work_keys_str_mv	AT alineroch singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT sonjagiger singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT mukulgirotra singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT vascocampos singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT nicolavannini singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT olaianaveiras singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT samygobaa singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells AT matthiasplutolf singlecellanalysesidentifybioengineerednichesforenhancedmaintenanceofhematopoieticstemcells
_version_	1718396637555982336

Single-cell analyses identify bioengineered niches for enhanced maintenance of hematopoietic stem cells

Ejemplares similares