Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon

Background: Preliminary testing of novel drugs for colorectal conditions must be performed on animal models, with invertebratemodels desirable for practical reasons. The insect excretory organs, the Malpighian tubules, have been cited as models for humanrenal disease research because they differenti...

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Autor principal:	Matan Shelomi
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2019
Materias:	transcriptomics colon protein carausius morosus model organism Medicine R
Acceso en línea:	https://doaj.org/article/2a3e1d51b5ae4a02994b135363e562db
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spelling	oai:doaj.org-article:2a3e1d51b5ae4a02994b135363e562db2021-11-14T08:42:16ZCarausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon2783-2430https://doaj.org/article/2a3e1d51b5ae4a02994b135363e562db2019-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46323_d7218bfcdef3673c414b8a41ae9e0050.pdfhttps://doaj.org/toc/2783-2430Background: Preliminary testing of novel drugs for colorectal conditions must be performed on animal models, with invertebratemodels desirable for practical reasons. The insect excretory organs, the Malpighian tubules, have been cited as models for humanrenal disease research because they differentially express several genes homologous to those differentially expressed in humankidneys. Their role in excretion and homeostasis suggests that they could be models for human colorectal disease. The insect Carausiusmorosus (Phasmatodea) has been a model organism for decades. Regarding its potential use as a colorectal disease model,it has an advantage over other insects in that excretion in Phasmatodea is split between two organs: Malpighian tubules and thePhasmatodea-specific “appendices of the midgut”.Objectives: To find homologues of human colon genes expressed in the excretory tissues of C. morosus for potential use in drugtesting and other experiments requiring an animal model.Methods: Pre-existing transcriptomics data for the excretory system of the C. morosus were examined to find genes homologous tothose known to have elevated expression in the human colon. This was done with the goal of possibly determining the excretorytissues in which they are differentially expressed.Results: Exactly sixty transcripts from the excretory system transcriptome of C. morosus showed high sequence homology withhuman colon-specific genes, with a minimum e-value of 1e-50. Examples include solute carriers, myosin, bestrophin, carbonic anhydrase,and nitric oxide synthase. Several genes were identified with prognostic value for renal, pancreatic, endometrial, liver, skin,and urothelial cancers.Conclusions: C. morosus can be used as model insect for human medical research applications, including colorectal drug testing.Matan ShelomiShiraz University of Medical Sciencesarticletranscriptomicscolonproteincarausius morosusmodel organismMedicineRENIranian Journal of Colorectal Research, Vol 7, Iss 2, Pp 1-4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcriptomics colon protein carausius morosus model organism Medicine R
spellingShingle	transcriptomics colon protein carausius morosus model organism Medicine R Matan Shelomi Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon
description	Background: Preliminary testing of novel drugs for colorectal conditions must be performed on animal models, with invertebratemodels desirable for practical reasons. The insect excretory organs, the Malpighian tubules, have been cited as models for humanrenal disease research because they differentially express several genes homologous to those differentially expressed in humankidneys. Their role in excretion and homeostasis suggests that they could be models for human colorectal disease. The insect Carausiusmorosus (Phasmatodea) has been a model organism for decades. Regarding its potential use as a colorectal disease model,it has an advantage over other insects in that excretion in Phasmatodea is split between two organs: Malpighian tubules and thePhasmatodea-specific “appendices of the midgut”.Objectives: To find homologues of human colon genes expressed in the excretory tissues of C. morosus for potential use in drugtesting and other experiments requiring an animal model.Methods: Pre-existing transcriptomics data for the excretory system of the C. morosus were examined to find genes homologous tothose known to have elevated expression in the human colon. This was done with the goal of possibly determining the excretorytissues in which they are differentially expressed.Results: Exactly sixty transcripts from the excretory system transcriptome of C. morosus showed high sequence homology withhuman colon-specific genes, with a minimum e-value of 1e-50. Examples include solute carriers, myosin, bestrophin, carbonic anhydrase,and nitric oxide synthase. Several genes were identified with prognostic value for renal, pancreatic, endometrial, liver, skin,and urothelial cancers.Conclusions: C. morosus can be used as model insect for human medical research applications, including colorectal drug testing.
format	article
author	Matan Shelomi
author_facet	Matan Shelomi
author_sort	Matan Shelomi
title	Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon
title_short	Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon
title_full	Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon
title_fullStr	Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon
title_full_unstemmed	Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon
title_sort	carausius morosus(phasmatodea) homologues of human genes withelevated expression in the colon
publisher	Shiraz University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/2a3e1d51b5ae4a02994b135363e562db
work_keys_str_mv	AT matanshelomi carausiusmorosusphasmatodeahomologuesofhumangeneswithelevatedexpressioninthecolon
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Carausius morosus(Phasmatodea) Homologues of Human Genes withElevated Expression in the Colon

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